Transcription Factor
| Accessions: | TEAD4_DBD (HumanTF 1.0), TEAD4_TF1 (HumanTF2 1.0) |
| Names: | TEA domain family member 4, TEAD-4, TEAD4, TEAD4_HUMAN, Transcription factor 13-like 1, Transcription factor RTEF-1, Transcriptional enhancer factor TEF-3 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q15561 |
| Notes: | Ensembl ID: ENSG00000197905; DNA-binding domain sequence; TF family: TEA/ATTS; Clone source: Gene synthesis, Ensembl ID: ENSG00000197905; Construct type: TF1(SBP); TF family: TEA; Clone source: Jolma et al. 2013 |
| Length: | 109 |
| Pfam Domains: | 4-100 TEA/ATTS domain family |
| Sequence: (in bold interface residues) | 1 PEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRN 60 61 ELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKFWQGALPGQ |
| Interface Residues: | 56, 60, 77, 78, 81, 82, 85, 86, 89 |
| 3D-footprint Homologues: | 5gzb_A, 5no6_N |
| Binding Motifs: | TEAD4_DBD crmATTCCwy TEAD4_ALX4_1 GGAATGytAamytAATTa TEAD4_ALX4_2 rCATwcCkyshTAATyrrATTA TEAD4_CEBPB rTTGCGyAAyvsckhGGaATGy TEAD4_CEBPD_1 rgwATgygrTTrCGyAAy TEAD4_CEBPD_2 rTTrCGCAAymcymwahGgAATGy TEAD4_CEBPD_2_3 rTTrCGCAAymmcktwrgwATGy TEAD4_CEBPD_2_3_4 rTTrCGyAAyayhwwggwATky TEAD4_CLOCK_1 rCAcRTGybmcarcATwCy TEAD4_CLOCK_2 vCACGTGymmyycrCATwCC TEAD4_CLOCK_2_3 GGwATGygkskvCACGTGk TEAD4_CLOCK_2_3_4 GGwATGykrskkrCACGTGb TEAD4_DLX2_1 rmATwcyargyaATTA TEAD4_DLX2_2 rCATwCyacwryAATTA TEAD4_DLX2_2_3 rmATwcywyssTAATtr TEAD4_DLX2_2_3_4 ggwATGtTAATkr TEAD4_DLX2_2_3_4_5 crCATwCCryvmTAATtrc TEAD4_DLX2_2_3_4_5_6 crCATwCCrvsyaATTA TEAD4_DLX3_1 rCATwCCrhsyaATTA TEAD4_DLX3_2 rCATwCytyssTAATtr TEAD4_DLX3_2_3 rCATwCCdysstAAtkr TEAD4_DLX3_2_3_4 rCATwCCrmsyaATTA TEAD4_DRGX_1 gghATGyTAATTr TEAD4_DRGX_2 GGwATGTTAATtr TEAD4_ELF1_1 rgAATGCGGAAGtr TEAD4_ELF1_2 gGAATGCGGAAGtr TEAD4_ELK1_1 ACCGGAhrTCCGGwATGh TEAD4_ELK1_2 rGAATsCGGAAGyg TEAD4_ELK1_2_3 rmATwCCGGAwgT TEAD4_ELK1_2_3_4 GGAATsCGGAAGtk TEAD4_ELK3 ACCGGAAGTdawmrMATwCy TEAD4_EOMES_1 ggyGybAMATwcytwtcrCrCy TEAD4_EOMES_2 rGaATGyGtkA- TEAD4_EOMES_2_3 wkGyGykAmATtcy TEAD4_EOMES_2_3_4 aggyGysACATTCCd TEAD4_EOMES_2_3_4_5 GGwATGyragGTGygr TEAD4_EOMES_2_3_4_5_6 rgGTGtkrssrkwGGwATGyg TEAD4_ERG_1 ACCGGAAATrCc TEAD4_ERG_2 aCCGGAArTrvawgrcATwCC TEAD4_ERG_2_3 rCCGGAAATrCC TEAD4_ESRRB_1 rcATwcywkddcAAGGTCAw TEAD4_ESRRB_2 rcATwcckstcAAGGTCA TEAD4_ETV1 acCGGAAaTrcc TEAD4_ETV4 ACCGGAAATrcC TEAD4_ETV7 rGAATGCGGAAGyrytTCCg TEAD4_FIGLA_1 GGwATKymCAssTG TEAD4_FIGLA_2 GGwATGyvCAssTG TEAD4_FIGLA_2_3 CATwCCacgvhatsymCAssTGs TEAD4_FLI1 ACCGGAAATrCc TEAD4_FOXI1_1 GGwATGyGtmmACa TEAD4_FOXI1_2 rCATTCCryayhmygcmawmyrwmAACA TEAD4_FOXI1_2_3 GCATwCCryrmmmwsyymmyrTmAACA TEAD4_FOXI1_2_3_4 rCATTCCabmrmmavgrvmrtmmACA TEAD4_FOXI1_2_3_4_5 rCaTtCCacmcysrmAgYGmmmaCA TEAD4_GATA3 wGATAAsrrwGGAATGy TEAD4_GSC2 ggwATGtTAATCsg TEAD4_HES7_1 GGwATGygkgrcrCGyGy TEAD4_HES7_2 ggwATGyrkgrsrCrCGyGb TEAD4_HES7_2_3 rcATwCCrvCrCGyGys TEAD4_HES7_2_3_4 rmATwCCacmsvCaCGyGys TEAD4_HOXA13_1 CTcGTAAATwCcr TEAD4_HOXA13_2 GGwATGCycrTWAA TEAD4_HOXA13_2_3 rCATwCCrcrmmmscymrTAAA TEAD4_HOXA13_2_3_4 rCATwCcdmrswaTTTAyrag TEAD4_HOXA2_1 rCATwCcrwdstmATTA TEAD4_HOXA2_2 rCATwCCrawctmATTA TEAD4_HOXA3_1 rCATwCyrwasymATTA TEAD4_HOXA3_2 rCATwCCrmmcymATTA TEAD4_HOXB13_1 mtyGTAAAATGyg TEAD4_HOXB13_2 symATAAAATGCr TEAD4_HOXB13_2_3 rGwATGCymrTaAa TEAD4_HOXB13_2_3_4 rGAATGCaaTaAA TEAD4_HOXB13_2_3_4_5 GGwATGCyyrTwAA TEAD4_HOXB13_2_3_4_5_6 stcrTAAAATGy TEAD4_MAX_1 GGwATGyrCACGTG TEAD4_MAX_2 rCATwCCdhmrrsCACGTG TEAD4_MAX_2_3 rmATwCCwcwhravCACGTG TEAD4_ONECUT2 rCATwCCryATYGAyy TEAD4_PAX5 rCATwcctyrwrskyasysrwSCGTGACs TEAD4_PITX1_1 rCATwcywraGGATTA TEAD4_PITX1_2 rCATtccrtasGgATTA TEAD4_PITX1_2_3 rCATwCywrhvyTAATCy TEAD4_PITX1_2_3_4 rCATwCCtmvyTAATCC TEAD4_PITX1_2_3_4_5 rCATwCCdyacTAATCC TEAD4_RFX5_1 rCATwCYwwwkksscywwwwyrGyAACv TEAD4_RFX5_2 rCATwCCwwamksssyywwtwtrgyAACs TEAD4_SOX15_1 rACAAwrraargwATGy TEAD4_SOX15_2 rACAAtrsrrhgGaATgy TEAD4_SOX6 rrACAATrgaawGGwATGy TEAD4_SPDEF_1 rGaATGCGGAyrt TEAD4_SPDEF_2 gGAATGCGGAtg TEAD4_SPDEF_2_3 rGwATGCGGAwrTrbaTCCGkby TEAD4_SPIB_1 rGAATGCGGAAGTd TEAD4_SPIB_2 GGAATGCGGAAGTd TEAD4_TBX21_1 arGTGTGAATwcy TEAD4_TBX21_2 aGGTGTkRmsdvtrgwATGy TEAD4_TCF3 rCAGsTGmGwATkyr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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