DNA Binding Motif

						

			
Accessions: TEAD4_CLOCK_2 (HumanTF2 1.0)

			
Names: TEAD4_CLOCK
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 20
Consensus: vCACGTGymmyycrCATwCC
Weblogo: 
PSSM: P0      A      C      G      T
01    200    156    140     21      v
02     35    516      0     19      C
03    516      5     31      0      A
04      7    516      0     81      C
05    110     16    516      0      G
06      2     46      8    516      T
07      8     12    516     43      G
08     13    195     77    232      y
09    215    168     52     80      m
10    193    161     56    106      m
11     97    176     64    179      y
12     91    158    127    139      y
13     63    234     96    124      c
14    238     35    221     22      r
15    120    516     20      1      C
16    516      8     47      0      A
17     10      7      0    516      T
18    210     19     34    306      w
19     58    516     35     34      C
20     18    516     24    141      C
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
TEAD4_TF1 (TEA/ATTS domain family)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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