DNA Binding Motif

						

			
Accessions: TEAD4_SPDEF_1 (HumanTF2 1.0), UN0585.1 (JASPAR 2024)

			
Names: TEAD4_SPDEF, TEAD4::SPDEF
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 13
Consensus: rGaATGCGGAyrt
Weblogo: 
PSSM: P0      A      C      G      T
01    240     18    537     79      r
02     14    212    777     15      G
03    777    174      5    226      a
04    777      4      0     10      A
05      0    106      6    777      T
06      0     61    777     17      G
07     47    777      6     36      C
08     12     20    777     16      G
09     14     48    777     24      G
10    777     29     24    113      A
11    174    307     47    603      y
12    346    150    431    112      r
13    142    225     64    777      t
Type: Heterodimer
Binding TFs: SPDEF_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
TEAD4_TF1 (TEA/ATTS domain family)
Q15561 (TEA/ATTS domain family)
Q15561
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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