Transcription Factor
| Accessions: | ELK1_DBD (HumanTF 1.0), ELK1_TF2 (HumanTF2 1.0) |
| Names: | ELK1, ELK1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P19419 |
| Notes: | Ensembl ID: ENSG00000126767; DNA-binding domain sequence; TF family: ETS; Clone source: MGC, Ensembl ID: ENSG00000126767; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 113 |
| Pfam Domains: | 5-87 Ets-domain |
| Sequence: (in bold interface residues) | 1 MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKL 60 61 SRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPN |
| Interface Residues: | 58, 59, 61, 62, 63, 65, 66, 80 |
| 3D-footprint Homologues: | 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | ELK1_DBD aCCGGAAGTr E2F1_ELK1_1 sGCGssyrAmCGGAAGt E2F1_ELK1_2 sGCGcshwtwkggrsCGGAAGt E2F1_ELK1_2_3 sGCGcsywdkkkrrrsCGGAAGT ELK1_EOMES_1 rrGyGygrrrryrgkrtsrCrCCGGAAgy ELK1_EOMES_2 rcCGGAAGTrgGyGygA ELK1_EOMES_2_3 tmrCACCGGAAgy ELK1_ETV7 amsCGGAMGGATdTCCGgyt ELK1_EVX1 rsCGGwAATgrymATTA ELK1_FOXI1_1 AsCGGAArTrTmAACAk ELK1_FOXI1_2 rCCGGAAGsWmArCAk ELK1_FOXI1_2_3 rmCGGAAGTTkw ELK1_FOXI1_2_3_4 wGyTkmCGGAwGTk ELK1_FOXI1_2_3_4_5 ammGGAAayrTAAAyA ELK1_FOXI1_2_3_4_5_6 ammGGAAbrtAAACA ELK1_HOXA1_1 aCCGGAAGTAAtTa ELK1_HOXA1_2 rCCGGAAGTvaTya ELK1_HOXA3_1 aCCGGwAAtkrkwyywcycATTAc ELK1_HOXA3_2 rcCGGwAAtkr- ELK1_HOXB13_1 rCCGGAAGThrTAAAa ELK1_HOXB13_2 rvCGGAArywrTwAaa ELK1_ONECUT2_1 rCCGGAAscGATCGATam ELK1_ONECUT2_2 rsCGGAAscGATCGATa ELK1_PAX1 aCCGGAACyACGCwTsRsYg ELK1_PAX5 aCCGGAACyACGCwYsAsyg ELK1_PAX9 rCCGGAACyACGCwysAmTk ELK1_SPDEF mcmGGAmGGAwATCCKgg ELK1_SREBF2_1 rcCGGAAGTsrCGTGA ELK1_SREBF2_2 rtCrCGTGACCGGAAGy ELK1_TBX21_1 aaGGtGtgrmrkkkmkttmrCrcCGGAAGyg ELK1_TBX21_2 tcrCACCGGAAgyr ELK1_TBX21_2_3 agGTGykAaawwwwwtTmaCACMGGAart ELK1_TBX21_2_3_4 TmaCACmGGAwvhg ELK1_TEF rcCGGAaGTKACGTAAb FOXO1_ELK1_1 rsCGGAwGTTdtk FOXO1_ELK1_2 rwmAACAGGAAGtr FOXO1_ELK1_2_3 tgttgcCGGAAGt GCM1_ELK1_1 ATryGGGCGGAAmCGGAwsta GCM1_ELK1_2 rtGcGGGCGGAAGkg GCM1_ELK1_2_3 rtGcGGGCGGAAGkg GCM2_ELK1 rTryGGGCGGAAGTr HOXB13_ELK1 rcmGGAAGycrTAAAm HOXB2_ELK1_1 rcCGGAAGTmrTTA HOXB2_ELK1_2 TAATkrCCGGAAGTr HOXD12_ELK1_1 rrsCGGAAGTyGTAAAa HOXD12_ELK1_2 rsCGGAAGTmrTAAAA POU2F1_ELK1_1 aCCGGAwATGCAw POU2F1_ELK1_2 mCCGsATATGCAm TEAD4_ELK1_1 ACCGGAhrTCCGGwATGh TEAD4_ELK1_2 rGAATsCGGAAGyg TEAD4_ELK1_2_3 rmATwCCGGAwgT TEAD4_ELK1_2_3_4 GGAATsCGGAAGtk TFAP2C_ELK1 yGCCksrGGsgrCGGAAGyg |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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