DNA Binding Motif

						

			
Accessions: HOXB2_ELK1_1 (HumanTF2 1.0), MA1957.1 (JASPAR 2024)

			
Names: HOXB2_ELK1, HOXB2::ELK1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: rcCGGAAGTmrTTA
Weblogo: 
PSSM: P0      A      C      G      T
01    737     94    602    130      r
02    117   1019    319     45      c
03     54   1338      6     19      C
04      8      0   1338      6      G
05      0      0   1338      7      G
06   1338      0      0      4      A
07   1338      0     18     88      A
08     48     24   1338      3      G
09     11    159     22   1338      T
10    539    799    195    163      m
11    814     43    524     80      r
12     38     48     38   1338      T
13     88    352     47   1338      T
14   1338     64    161    218      A
Type: Heterodimer
Binding TFs: P19419 (Ets-domain)
ELK1_TF2 (Ets-domain)
ELK1_Full (Ets-domain)
HOXB2_TF1 (Homeobox domain)
ELK1_TF1 (Ets-domain)
P19419
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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