DNA Binding Motif

						

			
Accessions: FOXO1_ELK1_2 (HumanTF2 1.0), MA1954.1 (JASPAR 2024)

			
Names: FOXO1_ELK1, FOXO1::ELK1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: rwmAACAGGAAGtr
Weblogo: 
PSSM: P0      A      C      G      T
01    722    233    636     52      r
02    566     82    292    791      w
03   1010   1094     31    263      m
04   1357     36     57     53      A
05   1357     21     64     16      A
06     18   1357     23     55      C
07   1357    228     15      5      A
08      2      4   1357      6      G
09      9      7   1357     13      G
10   1357     33     16      7      A
11   1357     35     22    188      A
12    248    103   1357     19      G
13    195    377    234    980      t
14    448    148    490    272      r
Type: Heterodimer
Binding TFs: ELK1_TF2 (Ets-domain)
ELK1_Full (Ets-domain)
FOXO1_TF1 / FOXO1_TF2 (Fork head domain)
Q12778 (Fork head domain)
ELK1_TF1 (Ets-domain)
Q12778
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB. Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions. Nat Commun 11:124 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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