DNA Binding Motif

						

			
Accessions: ELK1_PAX5 (HumanTF2 1.0), UN0501.1 (JASPAR 2024)

			
Names: ELK1_PAX5, ELK1::PAX5
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 20
Consensus: aCCGGAACyACGCwYsAsyg
Weblogo: 
PSSM: P0      A      C      G      T
01   4742    658   1770    554      a
02    298   5856    494     83      C
03    131   6557      0      2      C
04      2      0   6563      1      G
05      0      0   6562      2      G
06   6562      1      0      6      A
07   6524      2     15    217      A
08     10   6337    385    341      C
09      3   2360      0   4203      y
10   6280     42    593     39      A
11    157   5995      2    986      C
12    282     33   6533      2      G
13      1   6221    972      6      C
14   3037    946    280   2843      w
15    250   1713      0   4752      Y
16     50   3614   2906    190      s
17   6100     79   1350     12      A
18   1323   2589   1667    984      s
19    552   2754    243   5214      y
20   1931    194   5371    795      g
Type: Heterodimer
Binding TFs: Q02548 ('Paired box' domain, Paired-box protein 2 C terminal)
ELK1_TF2 (Ets-domain)
ELK1_Full (Ets-domain)
PAX5_TF1 / PAX5_TF2 ('Paired box' domain)
ELK1_TF1 (Ets-domain)
Q02548
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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