Transcription Factor
| Accessions: | PAX5_HUMAN (HOCOMOCO 10), Q02548 (JASPAR 2024) |
| Names: | B-cell-specific transcription factor, BSAP, Paired box protein Pax-5, PAX5_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 391 |
| Pfam Domains: | 16-140 'Paired box' domain 282-390 Paired-box protein 2 C terminal |
| Sequence: (in bold interface residues) | 1 MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV 60 61 SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLA 120 121 ERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS 180 181 ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV 240 241 FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYP 300 301 IVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRF 360 361 PNPGLLGSPYYYSAAARGAAPPAAATAYDRH |
| Interface Residues: | 29, 61, 62, 64, 66, 67, 83, 86, 89, 131, 132, 133, 134, 136, 137, 140 |
| 3D-footprint Homologues: | 1pdn_C, 6pax_A, 1k78_A |
| Binding Motifs: | MA0014.2 vwrrkCAgysraGCrtRaC UN0501.1 aCCGGAACyACGCwYsAsyg UN0562.1 ccGTCACGCwyCATTrv PAX5_HUMAN.H10MO.A|M01422 scvdrgkCAgysraSCrkRAC MA0014.3 rrGCGTGACCmb MA0014.4 GCGTGACC UN0562.2 GTCACGCwyCATTrv |
| Binding Sites: | MA0014.4.11 / MA0014.4.6 MA0014.4.13 MA0014.2.1 MA0014.2.10 MA0014.2.11 MA0014.2.12 MA0014.2.13 MA0014.2.14 MA0014.2.15 MA0014.2.16 MA0014.2.17 MA0014.2.18 MA0014.2.19 MA0014.2.2 MA0014.2.20 MA0014.2.3 MA0014.2.4 MA0014.2.5 MA0014.2.6 MA0014.2.7 MA0014.2.8 MA0014.2.9 MA0014.3.1 MA0014.3.10 MA0014.3.11 MA0014.3.12 MA0014.3.13 MA0014.3.14 MA0014.3.15 MA0014.3.16 MA0014.3.17 MA0014.3.18 MA0014.3.19 MA0014.3.2 MA0014.3.20 MA0014.3.3 MA0014.3.4 MA0014.3.5 MA0014.3.6 MA0014.3.7 MA0014.3.8 MA0014.3.9 MA0014.4.1 MA0014.4.10 / MA0014.4.9 MA0014.4.12 MA0014.4.14 / MA0014.4.2 MA0014.4.15 MA0014.4.16 / MA0014.4.18 / MA0014.4.20 / MA0014.4.7 MA0014.4.17 MA0014.4.19 MA0014.4.3 MA0014.4.4 MA0014.4.5 MA0014.4.8 |
| Publications: | Czerny T., Schaffner G., Busslinger M. DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 7:2048-2061 (1993). [Pubmed] |
| Related annotations: | PaperBLAST |
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