DNA Binding Motif

						

			
Accessions: HOXB2_PAX5_1 (HumanTF2 1.0), UN0562.1 (JASPAR 2024)

			
Names: HOXB2_PAX5, HOXB2::PAX5
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 17
Consensus: ccGTCACGCwyCATTrv
Weblogo: 
PSSM: P0      A      C      G      T
01    202    338    165    181      c
02    103    470    185    127      c
03      2      7    886     94      G
04    205    127     14    886      T
05     13    886     10    125      C
06    886      3     17     11      A
07     13    886      0    157      C
08     75      1    886      0      G
09     11    886    295      6      C
10    295    220    128    243      w
11     30    361      2    493      y
12     49    886    185     45      C
13    886      3    200      2      A
14     73    195    105    886      T
15     17    178      2    886      T
16    886     13    467    153      r
17    307    315    258      6      v
Type: Heterodimer
Binding TFs: Q02548 ('Paired box' domain, Paired-box protein 2 C terminal)
HOXB2_TF1 (Homeobox domain)
PAX5_TF1 / PAX5_TF2 ('Paired box' domain)
Q02548
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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