Transcription Factor
| Accessions: | HOXB2_DBD (HumanTF 1.0), HOXB2_TF1 (HumanTF2 1.0), HOXB2 (HT-SELEX2 May2017) |
| Names: | Homeobox protein Hox-2.8, Homeobox protein Hox-2H, Homeobox protein Hox-B2, HOXB2, HXB2_HUMAN, K8, ENSG00000173917 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P14652 |
| Notes: | Ensembl ID: ENSG00000173917; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, Ensembl ID: ENSG00000173917; Construct type: TF1(SBP); TF family: Homeodomain; Clone source: Jolma et al. 2013, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 149 |
| Pfam Domains: | 72-128 Homeobox domain |
| Sequence: (in bold interface residues) | 1 EDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADG 60 61 LGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQ 120 121 NRRMKHKRQTQHREPPDGEPACPGALEDI |
| Interface Residues: | 72, 73, 74, 75, 113, 114, 116, 117, 120, 121, 124, 125, 128 |
| 3D-footprint Homologues: | 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 3d1n_M, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 1nk2_P, 2ld5_A, 7q3o_C, 1b72_A, 4cyc_A, 1ig7_A, 5hod_A, 3a01_E, 5jlw_D, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 1au7_A, 5zjt_E, 7psx_B, 3l1p_A, 1o4x_A, 1du0_A, 4qtr_D, 8g87_X |
| Binding Motifs: | HOXB2_DBD rstmATTArc HOXB2_ELF1_1 smGGAAGTmrTta HOXB2_ELF1_2 ggymATtArsrwksmGGAAGtr HOXB2_ELF1_2_3 gymATyAgsgraksmGGAAGtr HOXB2_ELF1_2_3_4 TaATkrwyvMGGAAGtr HOXB2_ELF1_2_3_4_5 TrAtkrswrsmGGAAGtr HOXB2_ELK1_1 rcCGGAAGTmrTTA HOXB2_ELK1_2 TAATkrCCGGAAGTr HOXB2_ELK3_1 aCCGGAAGTmrTtA HOXB2_ELK3_2 TrAygkgwacCGGAAGTr HOXB2_EOMES_1 rgGYGyTAATkg HOXB2_EOMES_2 trAtkrgGTGyka HOXB2_ESRRB_1 TAATkrcsatbtCAAGGTCA HOXB2_ESRRB_2 TAATkrcswbyCAAGGTCA HOXB2_ETV1 rCCGGAAATgr- HOXB2_ETV4 rCCGGAAATgrs HOXB2_ETV7_1 TrATgrcsmGGAAryrCTTCCgs HOXB2_ETV7_2 rscGGAArtavsymATTAr HOXB2_ETV7_2_3 rsmGGAAGTrrrgymrTYAg HOXB2_HOXB13_1 ymATCATCGTWAA HOXB2_HOXB13_2 cTCrTAAAatyA HOXB2_HOXB13_2_3 symATCmmrTAAAm HOXB2_NHLH1_1 stvaTTakgmmGCAGCTGCG HOXB2_NHLH1_2 ryvaTywrsgyCgCAGCTGCk HOXB2_NHLH1_2_3 dymrTywkyrkkmkCAGCTGCk HOXB2_PAX1_1 ysGTCACGChyCATTdm HOXB2_PAX1_2 rymaTtaGTCACGCwTsrcTG HOXB2_PAX5_1 ccGTCACGCwyCATTrv HOXB2_PAX5_2 vhmaTTaGTCACGCwTsrcTG HOXB2_PAX9_1 cccaTTaGTCACGCwTsRsTk HOXB2_PAX9_2 sGTCACGChYCATTwv HOXB2_PITX1_1 TaATkaygGGATTA HOXB2_PITX1_2 taATkrgGGATTA HOXB2_PITX1_2_3 taAtkrssrmGGATTA HOXB2_PITX1_2_3_4 TaATkrsrrGGATTA HOXB2_RFX5_1 symATTAscvcmyrGyAACs HOXB2_RFX5_2 TAATkrCmtrGCAAC HOXB2_RFX5_2_3 TAATkaccmtrGCAAC HOXB2_SOX15_1 ACAATrsmawssymaTya HOXB2_SOX15_2 ACAAwrsravsymATtA HOXB2_SOX15_2_3 ACAATrramsymATtA HOXB2_SOX15_2_3_4 symATtarsmamaCAAtr HOXB2_SOX15_2_3_4_5 stmATyasmvmvraCAATg HOXB2_SPDEF AmCCGGATgyrsgymATTA HOXB2_TBX21_1 ragGTGyTAATkr HOXB2_TBX21_2 agGTGTkrrkmgymATTwrCAs HOXB2_TBX21_2_3 trAtkAgGTGykA HOXB2_TBX3 rGGTGTTAATkr HOXB2_TCF3_1 vCACCTGcmmcymATyA HOXB2_TCF3_2 rCAssTGyrrsymATTA HOXB2_3 symATTAs HOXB2_methyl_1 syMATTAg HOXB2_methyl_2 rTCRTTAr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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