Transcription Factor
| Accessions: | PAX5_DBD (HumanTF 1.0), PAX5_TF1 (HumanTF2 1.0), PAX5_TF2 (HumanTF2 1.0) |
| Names: | B-cell-specific transcription factor, BSAP, Paired box protein Pax-5, PAX5, PAX5_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q02548 |
| Notes: | Ensembl ID: ENSG00000196092; DNA-binding domain sequence; TF family: PAX; Clone source: Gene synthesis, Ensembl ID: ENSG00000196092; Construct type: TF1(SBP); TF family: PAX; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000196092; Construct type: TF2(3xFLAG); TF family: PAX; Clone source: Jolma et al. 2013 |
| Length: | 164 |
| Pfam Domains: | 15-139 'Paired box' domain |
| Sequence: (in bold interface residues) | 1 DLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS 60 61 HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAE 120 121 RVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVT |
| Interface Residues: | 28, 60, 61, 63, 65, 66, 82, 85, 88, 130, 131, 132, 133, 135, 136, 139 |
| 3D-footprint Homologues: | 1k78_A, 1pdn_C, 6pax_A |
| Binding Motifs: | PAX5_DBD sGTYACGSwTsrsTrmdy ELK1_PAX5 aCCGGAACyACGCwYsAsyg ETV2_PAX5 aCCGGAACyACGCwTsAcyg HOXA3_PAX5 tcATTAGTCACGCwTsrcTr HOXB2_PAX5_1 ccGTCACGCwyCATTrv HOXB2_PAX5_2 vhmaTTaGTCACGCwTsrcTG TEAD4_PAX5 rCATwcctyrwrskyasysrwSCGTGACs |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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