DNA Binding Motif

						

			
Accessions: ELK1_SREBF2_1 (HumanTF2 1.0), MA1933.1 (JASPAR 2024)

			
Names: ELK1_SREBF2, ELK1::SREBF2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rcCGGAAGTsrCGTGA
Weblogo: 
PSSM: P0      A      C      G      T
01    533     53    439    290      r
02    175    779    193     50      c
03     13    973     15     59      C
04      3     17    973      0      G
05      0     12    973     34      G
06    973     10      1     31      A
07    973     11      8    204      A
08    122      2    848      0      G
09     12     30     15    973      T
10     74    481    492     82      s
11    436     10    537     10      r
12     30    973    114    113      C
13     51     68    973      5      G
14     88    127     31    973      T
15     51     48    973     45      G
16    973     37     86    186      A
Type: Heterodimer
Binding TFs: ELK1_TF2 (Ets-domain)
ELK1_Full (Ets-domain)
SREBF2_TF2 (Helix-loop-helix DNA-binding domain)
Q12772 (Helix-loop-helix DNA-binding domain)
ELK1_TF1 (Ets-domain)
SREBF2_TF1 (Helix-loop-helix DNA-binding domain)
Q12772
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Chatterjee R, Zhao J, He X, Shlyakhtenko A, Mann I, Waterfall JJ, Meltzer P, Sathyanarayana BK, FitzGerald PC, Vinson C. Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins. G3 (Bethesda) 2:1243-56 (2012). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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