DNA Binding Motif

						

			
Accessions: ELK1_HOXA1_1 (HumanTF2 1.0), MA1931.1 (JASPAR 2024)

			
Names: ELK1_HOXA1, ELK1::HOXA1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: aCCGGAAGTAAtTa
Weblogo: 
PSSM: P0      A      C      G      T
01     57      6     12     19      a
02      0     69     15      9      C
03      1     69      0      1      C
04      0      0     69      0      G
05      0      0     69      0      G
06     69      0      0      0      A
07     69      0      0      1      A
08      0      1     69      0      G
09      4      7      6     69      T
10     69     16      6      3      A
11     69      7      9      7      A
12      6     12     15     69      t
13      3      9      9     69      T
14     69     16     13     25      a
Type: Heterodimer
Binding TFs: P49639 (Homeobox domain)
ELK1_TF2 (Ets-domain)
ELK1_Full (Ets-domain)
HOXA1_TF2 (Homeobox domain)
ELK1_TF1 (Ets-domain)
HOXA1_Full (Homeobox domain)
P49639
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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