DNA Binding Motif

						

			
Accessions: ELK1_ONECUT2_1 (HumanTF2 1.0), UN0499.1 (JASPAR 2024)

			
Names: ELK1_ONECUT2, ELK1::ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 18
Consensus: rCCGGAAscGATCGATam
Weblogo: 
PSSM: P0      A      C      G      T
01    468     92    272     78      r
02    126    610    118      9      C
03     44    776     26      4      C
04      0      2    785      5      G
05      4     11    785      9      G
06    773      4      5     25      A
07    781      4      7     37      A
08     20    448    335      9      s
09     94    439    134    117      c
10     71     25    769     27      G
11    589     35    174     30      A
12     33     15     20    785      T
13     29    781     33     25      C
14    164     38    733     43      G
15    769     15     64     55      A
16     91     31     20    760      T
17    560    183    249    134      a
18    240    278    144    122      m
Type: Heterodimer
Binding TFs: P19419 (Ets-domain)
ELK1_TF2 (Ets-domain)
ELK1_Full (Ets-domain)
ONECUT2_TF2 (Homeobox domain, CUT domain)
ELK1_TF1 (Ets-domain)
ONECUT2_Full (Homeobox domain, CUT domain)
P19419
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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