Transcription Factor
| Accessions: | HOXB13_Full (HumanTF2 1.0) |
| Names: | HOXB13, HXB13_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q92826 |
| Notes: | Ensembl ID: ENSG00000159184; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013 |
| Length: | 285 |
| Pfam Domains: | 21-123 Hox protein A13 N terminal 217-273 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSPLTSHPAAPTLMPAVNYAPLDLPGSAEPP 60 61 KQCHPCPGVPQGTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTAGEEY 120 121 PSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNS 180 181 QMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKF 240 241 ITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKNSATP* |
| Interface Residues: | 215, 217, 218, 219, 220, 258, 259, 261, 262, 265, 266, 269, 270, 273 |
| 3D-footprint Homologues: | 6fqp_B, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 3cmy_A, 6a8r_A, 1nk2_P, 1zq3_P, 2lkx_A, 1jgg_B, 3lnq_A, 6es3_K, 2ld5_A, 7q3o_C, 4xrs_G, 7psx_B, 1b72_A, 3rkq_B, 5flv_I, 3a01_E, 5zjt_E, 4cyc_A, 2hdd_A, 2r5y_A, 1puf_B, 6m3d_C, 5jlw_D, 2hos_A, 2xsd_C, 1le8_A, 7xrc_C, 1e3o_C, 1au7_A, 1o4x_A, 1le8_B, 1du0_A, 6fqq_E, 5hod_A, 1mnm_C, 4qtr_D, 1k61_B |
| Binding Motifs: | CUX1_HOXB13 symrTAAAhATyGATy ELK1_HOXB13_1 rCCGGAAGThrTAAAa ELK1_HOXB13_2 rvCGGAArywrTwAaa ERF_HOXB13 rccGGAaryhrTwAaa ETV2_HOXB13_1 rvCGGAwrymrTwAam ETV2_HOXB13_2 aCCGGAwmyATwAAm ETV5_HOXB13 rsCGGAwGYmrTwAa FLI1_HOXB13_1 rccGGAArymrTwAa FLI1_HOXB13_2 ACCGGAAGTCRTAAAa FOXJ2_HOXB13_1 tTTwAykdgwmAACA FOXJ2_HOXB13_2 rtmaAcaymrTaAaa FOXJ2_HOXB13_2_3 rTAAACwwATWAAa FOXJ2_HOXB13_2_3_4 kTTwAykrymaACA FOXO1_HOXB13_1 vwmmACAmmcymrTaAA FOXO1_HOXB13_2 rwmAACAymrTwAA FOXO1_HOXB13_2_3 rwmaACAsymrTwAAa GCM1_HOXB13_1 rTGcGGGTmATaAaw GCM1_HOXB13_2 aCCCsCAcCmATAAM GCM1_HOXB13_2_3 rCCCgyAysymrTAAm GCM1_HOXB13_2_3_4 rTGcGGGTmATAAAm HOXB13_ELK1 rcmGGAAGycrTAAAm HOXB13_EOMES_1 aggTGtswmATwAAa HOXB13_EOMES_2 cymrTwAawtmaCAccy HOXB13_ETV1 rCCGGAAgTawwaAAa HOXB13_ONECUT2_1 syhrTwAAwATyGAty HOXB13_ONECUT2_2 CYcrTAAAwaTCGaty HOXB13_TBX21_1 AgGTGTGAttkmwWAAAc HOXB13_TBX21_2 ArGTGtkAmcwATAAA HOXB13_TBX21_2_3 rgGTGTgAatTtATkr HOXB13_TBX3_1 cycrTAAwTcaCACst HOXB13_TBX3_2 cymrTAAAmsTcaCACcy HOXB2_HOXB13_1 ymATCATCGTWAA HOXB2_HOXB13_2 cTCrTAAAatyA HOXB2_HOXB13_2_3 symATCmmrTAAAm MEIS1_HOXB13 symrTwAAmcTGTCa POU2F1_HOXB13 wrmATAwwCmAATAAA TEAD4_HOXB13_1 mtyGTAAAATGyg TEAD4_HOXB13_2 symATAAAATGCr TEAD4_HOXB13_2_3 rGwATGCymrTaAa TEAD4_HOXB13_2_3_4 rGAATGCaaTaAA TEAD4_HOXB13_2_3_4_5 GGwATGCyyrTwAA TEAD4_HOXB13_2_3_4_5_6 stcrTAAAATGy TFAP2C_HOXB13 sCCksrRGGCRTcGTwAa |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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