DNA Binding Motif

						

			
Accessions: ETV2_HOXB13_2 (HumanTF2 1.0), MA1943.1 (JASPAR 2024)

			
Names: ETV2_HOXB13, ETV2::HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: aCCGGAwmyATwAAm
Weblogo: 
PSSM: P0      A      C      G      T
01   2545    720    953    573      a
02    725   4791    838    284      C
03    599   4791     42      6      C
04      0      0   4791      3      G
05      0      0   4791      0      G
06   4791     13     12      0      A
07   4791    804     14   2050      w
08   2114   1649   1003     25      m
09    722   2627     47   2164      y
10   4791     70   1344     76      A
11      8    270      0   4791      T
12   4791    166    231   2611      w
13   4791     49     16    326      A
14   4791    773    312    442      A
15   1478   1879    624    810      m
Type: Heterodimer
Binding TFs: HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
Q92826 (Homeobox domain, Hox protein A13 N terminal)
ETV2_TF1 (Ets-domain)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
Q92826
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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