Transcription Factor
| Accessions: | HOXB13_DBD (HumanTF 1.0), HOXB13_TF1 (HumanTF2 1.0), HOXB13_TF2 (HumanTF2 1.0), HOXB13 (HT-SELEX2 May2017) |
| Names: | HOXB13, HXB13_HUMAN, ENSG00000159184 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q92826 |
| Notes: | Ensembl ID: ENSG00000159184; DNA-binding domain sequence; TF family: homeodomain; Clone source: MGC, Ensembl ID: ENSG00000159184; Construct type: TF1(SBP); TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000159184; Construct type: TF2(3xFLAG); TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 115 |
| Pfam Domains: | 48-104 Homeobox domain |
| Sequence: (in bold interface residues) | 1 QSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLR 60 61 ELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKNSATP |
| Interface Residues: | 46, 48, 49, 50, 51, 59, 75, 77, 89, 90, 92, 93, 96, 97, 100, 101, 104 |
| 3D-footprint Homologues: | 6fqp_B, 1puf_A, 1ig7_A, 3cmy_A, 6a8r_A, 5zfz_A, 1fjl_B, 2h1k_B, 2lkx_A, 3lnq_A, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 2ld5_A, 1b72_A, 5zjt_E, 4cyc_A, 5hod_A, 2hdd_A, 2r5y_A, 1puf_B, 1jgg_B, 6m3d_C, 5jlw_D, 2hos_A, 4xrs_G, 1au7_A, 3rkq_B, 5flv_I, 3a01_E, 7psx_B, 6vz3_A, 1e3o_C, 2xsd_C, 6fqq_E, 1mnm_C, 1du0_A, 4qtr_D, 1k61_B, 1o4x_A, 1le8_B |
| Binding Motifs: | HOXB13_DBD_1 CCaATAAAAm HOXB13_DBD_2 sCTCGTAAAah CUX1_HOXB13 symrTAAAhATyGATy ELK1_HOXB13_1 rCCGGAAGThrTAAAa ELK1_HOXB13_2 rvCGGAArywrTwAaa ERF_HOXB13 rccGGAaryhrTwAaa ETV2_HOXB13_1 rvCGGAwrymrTwAam ETV2_HOXB13_2 aCCGGAwmyATwAAm ETV5_HOXB13 rsCGGAwGYmrTwAa FLI1_HOXB13_1 rccGGAArymrTwAa FLI1_HOXB13_2 ACCGGAAGTCRTAAAa FOXJ2_HOXB13_1 tTTwAykdgwmAACA FOXJ2_HOXB13_2 rtmaAcaymrTaAaa FOXJ2_HOXB13_2_3 rTAAACwwATWAAa FOXJ2_HOXB13_2_3_4 kTTwAykrymaACA FOXO1_HOXB13_1 vwmmACAmmcymrTaAA FOXO1_HOXB13_2 rwmAACAymrTwAA FOXO1_HOXB13_2_3 rwmaACAsymrTwAAa GCM1_HOXB13_1 rTGcGGGTmATaAaw GCM1_HOXB13_2 aCCCsCAcCmATAAM GCM1_HOXB13_2_3 rCCCgyAysymrTAAm GCM1_HOXB13_2_3_4 rTGcGGGTmATAAAm HOXB13_ELK1 rcmGGAAGycrTAAAm HOXB13_EOMES_1 aggTGtswmATwAAa HOXB13_EOMES_2 cymrTwAawtmaCAccy HOXB13_ETV1 rCCGGAAgTawwaAAa HOXB13_ONECUT2_1 syhrTwAAwATyGAty HOXB13_ONECUT2_2 CYcrTAAAwaTCGaty HOXB13_TBX21_1 AgGTGTGAttkmwWAAAc HOXB13_TBX21_2 ArGTGtkAmcwATAAA HOXB13_TBX21_2_3 rgGTGTgAatTtATkr HOXB13_TBX3_1 cycrTAAwTcaCACst HOXB13_TBX3_2 cymrTAAAmsTcaCACcy HOXB2_HOXB13_1 ymATCATCGTWAA HOXB2_HOXB13_2 cTCrTAAAatyA HOXB2_HOXB13_2_3 symATCmmrTAAAm MEIS1_HOXB13 symrTwAAmcTGTCa POU2F1_HOXB13 wrmATAwwCmAATAAA TEAD4_HOXB13_1 mtyGTAAAATGyg TEAD4_HOXB13_2 symATAAAATGCr TEAD4_HOXB13_2_3 rGwATGCymrTaAa TEAD4_HOXB13_2_3_4 rGAATGCaaTaAA TEAD4_HOXB13_2_3_4_5 GGwATGCyyrTwAA TEAD4_HOXB13_2_3_4_5_6 stcrTAAAATGy TFAP2C_HOXB13 sCCksrRGGCRTcGTwAa HOXB13_2 sCTCGTAAAay HOXB13_3 cCCmATAAAAc HOXB13_methyl_1 sCTCGTAAAAh |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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