DNA Binding Motif

						

			
Accessions: GCM1_HOXB13_2_3_4 (HumanTF2 1.0), UN0547.1 (JASPAR 2024)

			
Names: GCM1_HOXB13, GCM1::HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: rTGcGGGTmATAAAm
Weblogo: 
PSSM: P0      A      C      G      T
01    619     54    342     96      r
02     47     58     19    969      T
03    284     21    900      0      G
04    162    796    149    197      c
05     49     20    948     90      G
06      2      3    989     19      G
07      2      1    991      4      G
08      0     55     21    962      T
09    808    524      3     49      m
10    966     17     44      8      A
11      0     48     13    969      T
12    914     28     74    192      A
13    958      2     41     52      A
14    915    119    115    111      A
15    335    255    235    163      m
Type: Heterodimer
Binding TFs: GCM1_TF1 (GCM motif protein)
HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
Q9NP62 (GCM motif protein)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
Q9NP62
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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