DNA Binding Motif

						

			
Accessions: FLI1_HOXB13_2 (HumanTF2 1.0), UN0531.1 (JASPAR 2024)

			
Names: FLI1_HOXB13, FLI1::HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; PWM is from validation experiment performed with full-length TFs and is not included into the dendrograms, HT-SELEX
Length: 16
Consensus: ACCGGAAGTCRTAAAa
Weblogo: 
PSSM: P0      A      C      G      T
01    316      3     44     27      A
02      0    391     12      0      C
03      5    391      0      2      C
04      0      4    391      6      G
05     44      0    391      6      G
06    391      0      1      0      A
07    391      0     14     26      A
08     26      6    359      0      G
09      0     82      0    391      T
10     88    271     11     20      C
11    104      1    287      7      R
12      0      0      0    391      T
13    391      0      0     53      A
14    391      8      0      2      A
15    391      0     13      2      A
16    203     86     22     80      a
Type: Heterodimer
Binding TFs: FLI1_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_Full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
Q92826 (Homeobox domain, Hox protein A13 N terminal)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
Q92826
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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