DNA Binding Motif

Accessions: ERF_HOXB13 (HumanTF2 1.0), MA1937.1 (JASPAR 2024)
Names: ERF_HOXB13, ERF::HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rccGGAaryhrTwAaa
Weblogo:
PSSM: P0 A C G T
01 741 427 656 316 r
02 450 960 484 247 c
03 545 1597 249 35 c
04 19 4 2141 7 G
05 28 0 2141 36 G
06 2141 49 28 41 A
07 2141 284 84 725 a
08 845 193 1296 37 r
09 69 795 93 1184 y
10 619 634 335 554 h
11 1067 94 1074 287 r
12 21 175 98 2141 T
13 2141 213 355 1253 w
14 2141 18 86 294 A
15 2141 463 284 428 a
16 696 501 503 441 a
Type: Heterodimer
Binding TFs: HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
Q92826 (Homeobox domain, Hox protein A13 N terminal)
ERF_TF1 (Ets-domain)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
Q92826
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

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