DNA Binding Motif

						

			
Accessions: ERF_HOXB13 (HumanTF2 1.0), MA1937.1 (JASPAR 2024)

			
Names: ERF_HOXB13, ERF::HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rccGGAaryhrTwAaa
Weblogo: 
PSSM: P0      A      C      G      T
01    741    427    656    316      r
02    450    960    484    247      c
03    545   1597    249     35      c
04     19      4   2141      7      G
05     28      0   2141     36      G
06   2141     49     28     41      A
07   2141    284     84    725      a
08    845    193   1296     37      r
09     69    795     93   1184      y
10    619    634    335    554      h
11   1067     94   1074    287      r
12     21    175     98   2141      T
13   2141    213    355   1253      w
14   2141     18     86    294      A
15   2141    463    284    428      a
16    696    501    503    441      a
Type: Heterodimer
Binding TFs: HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
Q92826 (Homeobox domain, Hox protein A13 N terminal)
ERF_TF1 (Ets-domain)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
Q92826
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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