DNA Binding Motif

Accessions: MEIS1_HOXB13 (HumanTF2 1.0)
Names: MEIS1_HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 15
Consensus: symrTwAAmcTGTCa
Weblogo:
PSSM: P0 A C G T
01 2052 3797 2837 639 s
02 594 3668 291 2965 y
03 3414 3220 721 1765 m
04 3466 518 3168 510 r
05 42 491 36 6634 T
06 6634 199 1088 2775 w
07 6634 61 39 908 A
08 6634 822 109 670 A
09 2392 2154 1199 890 m
10 2920 6634 3170 587 c
11 469 1966 191 6634 T
12 724 32 6634 126 G
13 565 1658 78 6634 T
14 33 6634 20 120 C
15 6634 1027 1577 1976 a
Type: Heterodimer
Binding TFs: HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
MEIS1_TF1 (Homeobox domain, Homeobox KN domain)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
MEIS1_Crystal (Homeobox domain, Homeobox KN domain)
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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