DNA Binding Motif

						

			
Accessions: TFAP2C_HOXB13 (HumanTF2 1.0)

			
Names: TFAP2C_HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 18
Consensus: sCCksrRGGCRTcGTwAa
Weblogo: 
PSSM: P0      A      C      G      T
01    166    441    665     29      s
02     19   1106     14      6      C
03     16   1106     12    314      C
04     98    244    333    431      k
05    203    392    423     87      s
06    422    163    326    195      r
07    327      0    786      0      R
08      0     21   1106      0      G
09    122    198   1106    128      G
10     84   1106     98    181      C
11   1106     55    434     17      R
12      0    201      0   1106      T
13    108    724     40    234      c
14    299     20   1106     79      G
15     31      4     38   1106      T
16    796     54     61    310      w
17   1106     36      1     28      A
18   1106    214    177    188      a
Type: Heterodimer
Binding TFs: HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
TFAP2C_TF1 (Transcription factor AP-2)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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