footprintDB - a database of transcription factors with annotated cis elements (DNA motifs and sites) and binding interfaces

Database 'UniPROBE 20160601' (Transcription Factors 151-200)

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Pages: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14

Accessions	Names	Organisms	Description and notes
UP00080A	GATA binding protein 5, GATA-binding factor 5, Gata5, Transcription factor	Mus musculus	GATA binding protein 5
UP00100A	AA410133, GATA binding protein 6, GATA-6, GATA-binding factor 6, Gata6, factor GATA-6	Mus musculus	GATA binding protein 6
UP00204A	Gastrulation and brain-specific homeobox protein 1, gastrulation brain homeobox 1, Homeobox protein GBX-1	Mus musculus	gastrulation brain homeobox 1
UP00131A	D130058E05Rik, Gastrulation and brain-specific homeobox protein 2, gastrulation brain homeobox Gbx-2, Gbx2, Homeobox protein GBX-2, Homeobox protein STRA7, Mmoxa	Mus musculus	gastrulation brain homeobox 2
UP00070A	Chorion-specific transcription factor GCMa, Gcm 1, Gcm a, GCM motif 1, Gcm-rs2, Gcm1, Gcm1-rs1, glial cell deficient, glial cells missing homolog 1 (Drosophila), glide, mGCM1, mGCMa	Mus musculus	glial cells missing homolog 1 (Drosophila)
UP00285A	AAS3, Amino acid biosynthesis regulatory protein, ARG9, Gcn4, General control GCN4, YEL009C	Saccharomyces cerevisiae	Transcriptional activator of amino acid biosynthetic genes in response to acid starvation; expression is tightly regulated at both the transcriptional and translational levels
UP00428A	AAS3, Amino acid biosynthesis regulatory protein, ARG9, GCN4, General control GCN4, YEL009C	Saccharomyces cerevisiae	Transcriptional activator of amino acid biosynthetic genes in response to acid starvation; expression is tightly regulated at both the transcriptional and translational levels
UP00456A	Gcr1, GlyColysis Regulation, LPF10	Saccharomyces cerevisiae	GlyColysis Regulation : Transcriptional activator of genes involved in glycolysis; protein that interacts and functions with the transcriptional activator Gcr2p
UP00591B	FLJ94509, GFI1_L400F, Growth factor independent protein 1, SCN2, Zinc finger 163, zinc finger protein Gfi-1, ZNF163	Homo sapiens	zinc finger protein Gfi-1: Transcription repressor essential for hematopoiesis. Functions a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promo
UP00591C	FLJ94509, GFI1_N382S, Growth factor independent protein 1, SCN2, Zinc finger 163, zinc finger protein Gfi-1, ZNF163	Homo sapiens	zinc finger protein Gfi-1: Transcription repressor essential for hematopoiesis. Functions a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promo
UP00591A	FLJ94509, GFI1_REF, Growth factor independent protein 1, SCN2, Zinc finger 163, zinc finger protein Gfi-1, ZNF163	Homo sapiens	zinc finger protein Gfi-1: Transcription repressor essential for hematopoiesis. Functions a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promo
UP00592B	GFI1B_A204T, Growth factor independent protein 1B, Potential regulator of CDKN1A in CML, zinc finger protein Gfi-1b	Homo sapiens	zinc finger protein Gfi-1b: Essential proto-oncogenic transcriptional regulator necessary for and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1
UP00592A	GFI1B_REF, Growth factor independent protein 1B, Potential regulator of CDKN1A in CML, zinc finger protein Gfi-1b	Homo sapiens	zinc finger protein Gfi-1b: Essential proto-oncogenic transcriptional regulator necessary for and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1
UP00538A	AV235269, GLI-Kruppel family member GLI1, Gli1, Glioma-associated oncogene homolog, Zfp-5, Zinc finger protein GLI1	Mus musculus	GLI-Kruppel family member GLI1: Acts as a transcriptional activator. May the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
UP00539A	AW546128, GLI-Kruppel family member GLI2, Gli2, Zinc finger protein GLI2	Mus musculus	GLI-Kruppel family member GLI2
UP00540A	add, AI854843, AU023367, Bph, brachyphalangy, GLI-Kruppel family member GLI3, Gli3, GLI3FL, Pdn, Transcriptional activator GLI3, Xt, Zinc finger protein GLI3	Mus musculus	GLI-Kruppel family member GLI3: Has a dual function as a activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repres
UP00024A	Gli5, GLIS family zinc finger 2, Glis2, Klf16, MGC36775, Nkl	Mus musculus	GLIS family zinc finger 2: GLIS family zinc finger 2 mRNA
UP00318A	Gln3, Nitrogen regulatory protein GLN3, YER040W	Saccharomyces cerevisiae	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), and activity regulated by quality of nitrogen source
UP00042A	(NCBI), gene model 397, Gm397, LOC245109	Mus musculus	gene model 397, (NCBI): Mus musculus similar to Zinc finger 58 (Zfp-58) (Zinc finger protein Mfg-1) (LOC212386), mRNA
UP00424A	EG232974, Gm4881, predicted gene 4881	Mus musculus	predicted gene 4881: Ensembl Gene ID:ENSMUSG00000042789,Transcript ID:ENSMUST00000061154.4,Protein ID:ENSMUSP00000056357
UP00423A	EG432800, Gm5454, Predicted gene 5454	Mus musculus	Predicted gene 5454: Ensembl Gene ID: ENSMUSG00000047643, Transcript ID: ENSMUST00000052030, ID: ENSMUSP00000055525
UP00084A	1110050A04Rik, AI256615, AI481278, glucocorticoid modulatory element binding protein 1, Glucocorticoid element-binding protein 1, GMEB-1, Gmeb1	Mus musculus	glucocorticoid modulatory element binding protein 1: transcription termination factor 1, (cDNA clone MGC:69635 IMAGE:6847867), complete cds
UP00112A	goosecoid, Gsc, Homeobox protein goosecoid	Mus musculus	goosecoid
UP00127A	genomic screened homeo box 2, Gsh-2, Gsh2, Homeobox protein GSH-2	Mus musculus	genomic screened homeo box 2
UP00301A	Gsm1, J0824, Putative 70.4 kDa transcriptional regulatory protein in IME2-MEF2 region	Saccharomyces cerevisiae	Putative zinc cluster protein of unknown function; computationally predicted involvement oxidative phosphorylation, based on patterns of expression and sequence analysis
UP00347A	DEH1, Gzf3, J0806, NIL2, Protein GZF3, YJL110C	Saccharomyces cerevisiae	GATA zinc finger protein and Dal80p homolog that negatively regulates catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source;...
UP00457A	ERN4, Hac1, Homologous to Atf/Creb1, IRE15	Saccharomyces cerevisiae	Homologous to Atf/Creb1 : Basic leucine zipper (bZIP) transcription factor homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis
UP00315A	Hal9, Halotolerance protein 9, O0938, YOL089C	Saccharomyces cerevisiae	Putative transcription factor containing a zinc finger; overexpression increases salt through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decrease...
UP00458A	CYP1, Hap1, Heme Activator Protein	Saccharomyces cerevisiae	Heme Activator Protein : Zinc finger transcription factor involved in complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
UP00055A	1700058O05Rik, BE629963, C330012F01Rik, C86454, Hbp1, high mobility group box transcription 1, HMG box transcription factor 1, HMG box-containing protein 1	Mus musculus	high mobility group box transcription factor 1
UP00148A	Hdx, Highly divergent homeobox, Not Available	Mus musculus	Highly divergent homeobox
UP00594B	ANF, CPHD5, hAnf, HESX1_E149K, homeobox expressed in ES cells 1, protein ANF, MGC138294, RPX	Homo sapiens	homeobox expressed in ES cells 1: Required for the normal of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).
UP00594C	ANF, CPHD5, hAnf, HESX1_N125S, homeobox expressed in ES cells 1, protein ANF, MGC138294, RPX	Homo sapiens	homeobox expressed in ES cells 1: Required for the normal of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).
UP00594D	ANF, CPHD5, hAnf, HESX1_R160C, homeobox expressed in ES cells 1, protein ANF, MGC138294, RPX	Homo sapiens	homeobox expressed in ES cells 1: Required for the normal of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).
UP00594A	ANF, CPHD5, hAnf, HESX1_REF, homeobox expressed in ES cells 1, protein ANF, MGC138294, RPX	Homo sapiens	homeobox expressed in ES cells 1: Required for the normal of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).
UP00035A	AA408311, Hic-1, Hic1, hypermethylated in cancer 1, Hypermethylated in cancer protein	Mus musculus	hypermethylated in cancer 1: Mus musculus hypermethylated in cancer 1
UP00387A	HLH-1, MyoD1	Caenorhabditis elegans	Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals
UP00548A	Helix Loop Helix Protein 1, HLH-1, MyoD1	Caenorhabditis elegans	Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals
UP00548B	Helix Loop Helix Protein 1, HLH-1_L13R, MyoD1	Caenorhabditis elegans	Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals
UP00548C	Helix Loop Helix Protein 1, HLH-1_L13T, MyoD1	Caenorhabditis elegans	Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals
UP00548D	Helix Loop Helix Protein 1, HLH-1_L13V, MyoD1	Caenorhabditis elegans	Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals
UP00358A	HLH-10	Caenorhabditis elegans	Helix Loop Helix Protein 10: none available
UP00357A	HLH-11	Caenorhabditis elegans	Helix Loop Helix Protein 11: none available
UP00363A	HLH-14	Caenorhabditis elegans	Helix Loop Helix Protein 14: hlh-14 encodes a basic helix-loop-helix transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendant
UP00361A	HLH-15	Caenorhabditis elegans	Helix Loop Helix Protein 15 : none available
UP00378A	HLH-19	Caenorhabditis elegans	Helix Loop Helix Protein 19 : none available
UP00384A	HLH-2	Caenorhabditis elegans	Helix Loop Helix Protein 2: hlh-2 encodes a Class I helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural
UP00386A	HLH-25	Caenorhabditis elegans	Helix Loop Helix Protein 25: hlh-25 encodes a REF-1-like protein two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-de
UP00370A	HLH-26	Caenorhabditis elegans	Helix Loop Helix Protein 26: hlh-26 encodes a REF-1-like protein two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-26 may require UNC-37; HLH-26's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; HLH-26 is not visibly ex
UP00364A	HLH-27	Caenorhabditis elegans	Helix Loop Helix Protein 27: hlh-27 encodes a REF-1-like protein two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is trans

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