Transcription Factor
| Accessions: | Gbx2_DBD (HumanTF 1.0), UP00131A (UniPROBE 20160601) |
| Names: | Gastrulation and brain-specific homeobox protein 2, Gbx2, GBX2_MOUSE, Homeobox protein GBX-2, Stimulated by retinoic acid gene 7 protein, D130058E05Rik, gastrulation brain homeobox 2, Gbx-2, Homeobox protein STRA7, Mmoxa |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P48031 |
| Description: | gastrulation brain homeobox 2 |
| Notes: | Ensembl ID: ENSMUSG00000034486; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 PQSGGAAGSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQV 60 61 KIWFQNRRAKWKRVKAGNANSKTGEPSRNPKIV |
| Interface Residues: | 17, 18, 19, 20, 22, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 3d1n_M, 5zfz_A, 1fjl_B, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 4j19_B, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 1au7_A, 2hos_A, 4cyc_A, 5flv_I, 1b72_A, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1mnm_C, 1k61_B, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00131A_1 dscrCTAATTAGysrkt Gbx2_DBD rsyAATTArs |
| Binding Sites: | GGTAATTA AATAATTA AATTAGCA AATTAGTG ACCAATTA ACTAATTA ACTAATTG AGTAATTA ATAATTAC ATAATTAG ATTAATTA CAATTAGC CCAATTAG CCTAATTA CTAATTAA CTAATTAC CTAATTGC GATAATTA GCTAATTA GTAATTAC |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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