Transcription Factor
| Accessions: | UP00548D (UniPROBE 20160601) |
| Names: | Helix Loop Helix Protein 1, HLH-1_L13V, MyoD1 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals |
| Length: | 324 |
| Pfam Domains: | 156-207 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MNTETSTQSAPSDTYDTSIYYNSSPRVTANDITTLTSFAAPAPQVLDYANTQYDIYRNQP 60 61 AYYLPSYAPTAPTTFYSDFANFNVTRSQDFASVPAVANSSDVKPIIIKQEKSTPNATELI 120 121 IQSRVDSQHEDTTTSTAGGAGVGGPRRTKFVLSVDRRKAATMRERRRVRKVNEAFEVVKQ 180 181 RTCPNPNQRLPKVEILRSAIDYINNLERMLQQAGKMTKIMEQNQHLQMTQQINGAPPHDY 240 241 VTSSHFASSSYNPENMFDDDDLTDSDDDRDHHKLGNAVDLRRRNSLDRLSRIVASIPNEE 300 301 AMTDEQLLQPANDVIDGEKKLEML |
| Interface Residues: | 157, 160, 161, 163, 164, 165, 167, 168, 184, 185, 188, 189, 192, 198 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D, 8i54_A, 5xut_A |
| Binding Motifs: | UP00548D_1 mrkrkrkRACAGcTGTymgrkmm |
| Binding Sites: | AACACCTG AACAGCTG AACAGGTG ACACCTGC ACACCTGT ACAGCTGC ACAGCTGT ACAGGTGA ACAGGTGC AGCAGCTG AGCAGGTG CACCTGAC CACCTGTC CAGCTGAC CAGCTGTC CAGGTGAC ACAGATGT ACATATGT CAGGTGTC CATCTGTC |
| Publications: | De Masi F, Grove CA, Vedenko A, Alibés A, Gisselbrecht SS, Serrano L, Bulyk ML, Walhout AJ. Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants. Nucleic Acids Res 39:4553-63 (2011). [Pubmed] |
| Related annotations: | PaperBLAST |
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