DNA Binding Site
| Accessions: | ACACCTGC (UniPROBE 20160601), MA0830.3.14 (JASPAR 2024), MA0830.3.16 (JASPAR 2024), MA0830.3.18 (JASPAR 2024), MA1620.2.10 (JASPAR 2024), MA1620.2.6 (JASPAR 2024) |
| Organisms: | Mus musculus, Caenorhabditis elegans, Homo sapiens |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 8 |
| Sequence: | ACACCTGC |
| Type: | Heterodimer |
| Binding TFs: | UP00036A (Helix-loop-helix DNA-binding domain, Myogenic Basic domain) P15884 (Helix-loop-helix DNA-binding domain) UP00099A (Helix-loop-helix DNA-binding domain) UP00358A (Helix-loop-helix DNA-binding domain) UP00361A (Helix-loop-helix DNA-binding domain) UP00363A (Helix-loop-helix DNA-binding domain) UP00369A (Helix-loop-helix DNA-binding domain) UP00379A (Helix-loop-helix DNA-binding domain) UP00384A (Helix-loop-helix DNA-binding domain) UP00548A (Helix-loop-helix DNA-binding domain) UP00548D (Helix-loop-helix DNA-binding domain) UP00621A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621B (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621C (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) Q9QX98 (Helix-loop-helix DNA-binding domain) P15884 Q9QX98 |
| Binding Motifs: | UP00036A_1 rrrgrACAGbTGtyyg UP00099A_1 ytyarCAGCTGCtvytk UP00358A_1 wAyyAwATwTrgmm UP00361A_1 agwaaaawrwhdwr UP00363A_1 cwhaaaawawwwAa UP00369A_1 mawwaawaAaadgw UP00036A_2 vsmrmCAgmCgcrcc UP00099A_2 bymwcCCcryccyrty UP00358A_2 / UP00384A_3 yvsamCACCTGTTmcrg UP00361A_2 / UP00384A_5 rrmsCAsCTGbGccmt UP00363A_2 / UP00384A_4 ykaaCAbCTGTCvmda UP00369A_2 / UP00384A_8 arwwyCACCTGYthawy UP00379A_2 / UP00384A_7 mrtrmCACCTGCtaayy UP00548A_1 sGgamrGrCACGTGtCsyhCysy UP00548D_1 mrkrkrkRACAGcTGTymgrkmm UP00621A_1 wmkaratrCACCTGyTakwhmk UP00621B_1 wwwmrakrCACCTGyTakwhaw UP00621C_1 tadarAwrCACCTGyTakwyad MA0830.3 gCACCTGc MA1620.2 aCACCTGt |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed] Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE. Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility. Mol Cell Biol 33:3166-79 (2013). [Pubmed] |
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