DNA Binding Site
| Accessions: | ACACCTGT (UniPROBE 20160601), MA0745.3.19 (JASPAR 2024), MA0745.3.9 (JASPAR 2024), MA0830.3.4 (JASPAR 2024), MA1472.3.6 (JASPAR 2024), MA1619.2.11 (JASPAR 2024), MA1619.2.15 (JASPAR 2024), MA1619.2.7 (JASPAR 2024), MA1620.2.2 (JASPAR 2024), MA1620.2.3 (JASPAR 2024), MA1620.2.4 (JASPAR 2024), MA1620.2.5 (JASPAR 2024) |
| Organisms: | Mus musculus, Caenorhabditis elegans, Homo sapiens |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 8 |
| Sequence: | ACACCTGT |
| Type: | Heterodimer |
| Binding TFs: | UP00036A (Helix-loop-helix DNA-binding domain, Myogenic Basic domain) P15884 (Helix-loop-helix DNA-binding domain) UP00046A (Helix-loop-helix DNA-binding domain) UP00358A (Helix-loop-helix DNA-binding domain) UP00361A (Helix-loop-helix DNA-binding domain) UP00363A (Helix-loop-helix DNA-binding domain) UP00369A (Helix-loop-helix DNA-binding domain) UP00378A (Helix-loop-helix DNA-binding domain) UP00379A (Helix-loop-helix DNA-binding domain) UP00381A (Helix-loop-helix DNA-binding domain) UP00384A (Helix-loop-helix DNA-binding domain) O43623 (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00548A (Helix-loop-helix DNA-binding domain) Q9QYC3 (Helix-loop-helix DNA-binding domain) UP00548D (Helix-loop-helix DNA-binding domain) UP00621A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621B (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621C (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) Q9QX98 (Helix-loop-helix DNA-binding domain) O43623 P15884 Q9QX98 Q9QYC3 |
| Binding Motifs: | UP00036A_1 rrrgrACAGbTGtyyg UP00046A_1 atcmvCAGGTGcraamw UP00358A_1 wAyyAwATwTrgmm UP00361A_1 agwaaaawrwhdwr UP00363A_1 cwhaaaawawwwAa UP00369A_1 mawwaawaAaadgw UP00378A_1 ctwwramwwwmmaw UP00381A_1 akwraTwagwaswm UP00036A_2 vsmrmCAgmCgcrcc UP00046A_2 arrgcCAGATGkyyssg UP00358A_2 / UP00384A_3 yvsamCACCTGTTmcrg UP00361A_2 / UP00384A_5 rrmsCAsCTGbGccmt UP00363A_2 / UP00384A_4 ykaaCAbCTGTCvmda UP00369A_2 / UP00384A_8 arwwyCACCTGYthawy UP00378A_2 / UP00384A_6 kktrmCAksTGkymmh UP00379A_2 / UP00384A_7 mrtrmCACCTGCtaayy UP00381A_2 / UP00384A_10 hmgamCAgcTGkymtc UP00548A_1 sGgamrGrCACGTGtCsyhCysy UP00548D_1 mrkrkrkRACAGcTGTymgrkmm UP00621A_1 wmkaratrCACCTGyTakwhmk UP00621B_1 wwwmrakrCACCTGyTakwhaw UP00621C_1 tadarAwrCACCTGyTakwyad MA0745.3 gCACCTGT MA0830.3 gCACCTGc MA1472.3 ACAGCTGT MA1619.2 aCAGCTGt MA1620.2 aCACCTGt |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed] Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Joens MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev 31:154-171 (2017). [Pubmed] Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE. Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility. Mol Cell Biol 33:3166-79 (2013). [Pubmed] |
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