Transcription Factor
| Accessions: | T015230_1.02 (CISBP 1.02), Q9QYC3 (JASPAR 2024) |
| Names: | Bhlha15, T015230_1.02;, BHA15_MOUSE, bHLHb8, Class A basic helix-loop-helix protein 15, Class B basic helix-loop-helix protein 8, MIST-1, Muscle, intestine and stomach expression 1 |
| Organisms: | Mus musculus, Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 197 |
| Pfam Domains: | 73-124 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MKTKNRPPRRRTPMQDTEATPGEQTPDRPQSGSGGSELTKGLRSRTARASGGRGEVSRRR 60 61 QGSGGRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNY 120 121 IKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQQQQQQQVAGAMLGVTEDQPQ 180 181 GHLQRYSTQIHSFREGS |
| Interface Residues: | 38, 69, 74, 76, 77, 78, 80, 81, 82, 84, 85, 110 |
| 3D-footprint Homologues: | 5hp4_A, 2ypa_A, 7z5k_B, 1an4_A, 7ssa_L, 5i50_B, 5eyo_A, 6od3_F, 2ql2_A, 2ql2_D, 2ypa_B, 4h10_A, 5v0l_A, 5gnj_I, 7xhv_B, 7xi3_B |
| Binding Motifs: | M0218_1.02 sCATATGt MA0607.1 sCATATGt UN0509.1 rsCGGAAmCATATGk MA1472.2 smACAGCTGTks MA1472.3 ACAGCTGT |
| Binding Sites: | MA1472.3.6 MA1472.3.1 MA1472.3.14 / MA1472.3.18 / MA1472.3.20 / MA1472.3.7 MA1472.3.3 MA1472.3.10 / MA1472.3.9 MA1472.3.11 / MA1472.3.16 MA1472.2.19 MA1472.2.20 MA1472.2.1 / MA1472.2.3 MA1472.2.10 / MA1472.2.16 MA1472.2.11 / MA1472.2.19 MA1472.2.12 / MA1472.2.20 MA1472.2.13 MA1472.2.14 MA1472.2.15 MA1472.2.16 MA1472.2.17 MA1472.2.18 MA1472.2.2 / MA1472.2.4 MA1472.2.3 / MA1472.2.5 MA1472.2.4 / MA1472.2.6 MA1472.2.5 / MA1472.2.9 MA1472.2.10 / MA1472.2.6 MA1472.2.13 / MA1472.2.7 MA1472.2.14 / MA1472.2.8 MA1472.2.15 / MA1472.2.9 MA1472.3.2 MA1472.3.13 / MA1472.3.17 / MA1472.3.19 / MA1472.3.8 MA1472.3.4 MA1472.2.1 MA1472.2.11 MA1472.2.12 MA1472.2.17 MA1472.2.18 MA1472.2.2 MA1472.2.7 MA1472.2.8 MA1472.3.12 / MA1472.3.15 MA1472.3.5 |
| Publications: | Lemercier C., To R. Q., Carrasco R. A., Konieczny S. F. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD. EMBO J. 17:1412-22 (1998). [Pubmed] Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Joens MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev 31:154-171 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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