Transcription Factor
| Accessions: | UP00379A (UniPROBE 20160601) |
| Names: | HLH-3 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P90977 |
| Description: | Helix Loop Helix Protein 3: hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors. |
| Length: | 96 |
| Pfam Domains: | 18-70 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 TSTKIPSSSKSSVTKQTKQKRNERERKRVDQVNQGFVLLQERVPKAAGNKAKLSKVETLR 60 61 EAARYIQELQKQLGMSSTSFHNSMPADFPTPEQSPV |
| Interface Residues: | 21, 22, 24, 25, 28, 29, 53 |
| 3D-footprint Homologues: | 8osl_O, 4h10_B, 5eyo_A, 2ql2_D, 2ypa_A, 5i50_B, 1am9_A, 7z5k_B, 1an4_A, 5gnj_I |
| Binding Motifs: | UP00379A_1 ybtrvarwaaarwg UP00379A_2 mrtrmCACCTGCtaayy |
| Binding Sites: | AAATAATA AACACCTG AACACGTG AACAGGTG ACACCTGC ACACCTGT ACACGTGA ACAGCTGT ACCACCTG ACCACGTG AGCACGTG AGCAGGTG ATATAATA ATCACATG ATCACGTG ATTATTTA CACCTGCA CACCTGCC CACCTGCG CACCTGTC CACGTGAC CACGTGCA CAGCTGTC CAGGTGCA CATGTGAC CCACCTGC CCACGTGA CTCGTGAC GCACCTGC GCACGTGA GCACGTGC GCAGCTGC TATATATA TCACATGA TCACGTGA TCATATGA ACAGGTGG CACCTGGC CAGGTGGC CCATCTGC |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.