Transcription Factor
| Accessions: | UP00384A (UniPROBE 20160601) |
| Names: | HLH-2 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q17588 |
| Description: | Helix Loop Helix Protein 2: hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural |
| Length: | 398 |
| Pfam Domains: | 302-356 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 ADPNSQLTSATTVATAAIAQPQVMLPNAYDYPYNIDPTTIQMPDYWSGYHLNPYPPMQTT 60 61 DIDYSSAFLPTHPPTETPASVAAPTSATSDIKPIHATSSTSTTAPSTAPAPTSTTDVLEL 120 121 KPTTAPATNSAETSAIVAPQPLTNLTAPIDAMSSMYTWPQTYPGYLPPSEDNKASEAVNP 180 181 YISIPPTYTFGADPSVADFSSYQQQLAGQPNGLGGDTNLVDYNHQFPPAGMSPHFDPNGY 240 241 PGMTGMPPGSSASSVRNDKSASRATSRRRVQGPPSSGIPTRHSSSSRLSDNESMSDDKDT 300 301 DRRSQNNARERVRVRDINSAFKELGRMCTQHNQNTERNQTKLGILHNAVSVITQLEEQVR 360 361 QRNMNPKVMAGMKRKPDDDKMKMLDDNAPSAQFGHPRF |
| Interface Residues: | 155, 156, 303, 305, 306, 307, 309, 310, 311, 313, 314, 339 |
| 3D-footprint Homologues: | 7xur_A, 7z5k_B, 1an4_A, 6od3_F, 6g1l_A, 2ql2_A, 2ql2_D, 2ypa_B |
| Binding Motifs: | UP00384A_1 wbraatataawvht UP00384A_3 yvsamCACCTGTTmcrg UP00384A_2 mskaACAkCTGTyyaa UP00384A_5 rrmsCAsCTGbGccmt UP00384A_4 ykaaCAbCTGTCvmda UP00384A_8 arwwyCACCTGYthawy UP00384A_9 aymaACATmTGGtwkm UP00384A_6 kktrmCAksTGkymmh UP00384A_7 mrtrmCACCTGCtaayy UP00384A_10 hmgamCAgcTGkymtc |
| Binding Sites: | AAAATTTT AACACCTG AACAGATG AACAGCTG AACAGGTG AACATATG ACACCTGC ACACCTGG ACACCTGT ACACGCGC ACACGCGT ACAGCTGC ACAGCTGG ACAGCTGT ACAGGTGA ACAGGTGC ACATGCGC ACATGCGT ACCACCTG ACCACGCG ACCAGCTG ACGCATGG ACGCGTGG AGCAGCTG AGCAGGTG ATCACCTG CACACCTG CACAGCTG CACAGGTG CACCTGCA CACCTGCC CACCTGCG CACCTGTC CACGCATG CACGCGTA CACGCGTG CACGTGTC CAGCTGCG CAGCTGTC CAGGTGCA CAGGTGCG CATGCGTA CCACCTGC CCACGCGC CCAGGTGC CCATGCGC CGCATGGC CGCATGTC CGCGTGGC CGCGTGTC CGTGTGTC GCACCTGC GCAGCTGC GCGTGTCC TTAATTAA AACATCTG AACATGTG AATTTAGT ACAGATGG ACAGATGT ACAGGTGG ACATATGG ACATATGT ACATCTGC ACATCTGG ACATGTGG ACCACATG ACCAGATG ACCATATG ACCATCTG AGCAGATG CACATCTG CACATGTG CACCTGGC CAGATGGC CAGCTGGG CAGGTGAA CAGGTGGA CAGGTGGC CAGGTGTA CATATGGA CATATGGC CATATGGG CATATGTC CATCTGCC CATCTGTC CCAGATGG CCAGCTGG CCATATGC CCATATGG CCATCTGC GCAGGTGA TGTTAACA |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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