Transcription Factor
| Accessions: | PTF1A_MOUSE (HOCOMOCO 10), Q9QX98 (JASPAR 2024) |
| Names: | bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, Pancreas transcription factor 1 subunit alpha, Pancreas-specific transcription factor 1a, PTF1-p48, PTF1A_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9QX98 |
| Length: | 324 |
| Pfam Domains: | 162-212 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MDAVLLEHFPGGLDTFPSPYFDEEDFFTDQSSRDPLEDSDELLGDEQAEVEFLSHQLHEY 60 61 CYRDGACLLLQPAPSAAPHALAPPPLGDPGEPEDNVSYCCDAGAPLAAFPYSPGSPPSCL 120 121 AYPCAAVLSPGARLGGLNGAAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAF 180 181 EGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGSGAGGCGGPGGSRHLG 240 241 EDSPGNQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAKVWTP 300 301 EDPRKLNSKSFDNIENEPPFEFVS |
| Interface Residues: | 162, 165, 166, 168, 169, 170, 172, 173, 198 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 7rcu_E, 5i50_B, 6g1l_A, 4h10_A, 6od3_F, 5eyo_A, 2ypa_B, 2ql2_A, 2ql2_D, 8osl_P, 7ssa_L |
| Binding Motifs: | PTF1A_MOUSE.H10MO.C|M01312 crGGrAAmwsmaCAssTGysm MA1618.1 dmaCAGATGttkh MA1619.1 rmaCAGCTGtky MA1620.1 rmaCACCTGtky MA1618.2 aCAGATGtt MA1619.2 aCAGCTGt MA1620.2 aCACCTGt |
| Binding Sites: | MA1620.2.7 MA1620.2.10 / MA1620.2.6 MA1619.2.11 / MA1619.2.15 / MA1619.2.7 / MA1620.2.2 / MA1620.2.3 / MA1620.2.4 / MA1620.2.5 MA1619.2.18 MA1619.2.13 / MA1619.2.5 / MA1619.2.9 MA1619.2.4 MA1619.2.19 / MA1619.2.20 / MA1620.2.11 / MA1620.2.12 / MA1620.2.15 / MA1620.2.16 / MA1620.2.20 / MA1620.2.8 / MA1620.2.9 MA1619.2.2 MA1618.1.1 MA1618.1.10 MA1618.1.11 MA1618.1.12 MA1618.1.13 MA1618.1.14 MA1618.1.15 MA1618.1.16 MA1618.1.17 MA1618.1.18 MA1618.1.19 MA1618.1.2 MA1618.1.20 MA1618.1.3 MA1618.1.4 MA1618.1.5 MA1618.1.6 MA1618.1.7 MA1618.1.8 MA1618.1.9 MA1619.1.1 / MA1619.1.2 MA1619.1.10 / MA1619.1.8 MA1619.1.11 / MA1619.1.13 / MA1619.1.15 / MA1619.1.5 / MA1619.1.7 / MA1619.1.9 / MA1620.1.11 / MA1620.1.14 / MA1620.1.8 MA1619.1.10 / MA1619.1.12 / MA1619.1.14 / MA1619.1.16 / MA1619.1.6 / MA1619.1.8 / MA1620.1.12 / MA1620.1.15 / MA1620.1.9 MA1619.1.11 / MA1619.1.13 / MA1619.1.15 / MA1619.1.17 / MA1620.1.13 / MA1620.1.16 / MA1620.1.2 / MA1620.1.4 / MA1620.1.5 / MA1620.1.7 MA1619.1.12 / MA1619.1.14 / MA1619.1.16 / MA1619.1.18 MA1619.1.17 / MA1619.1.19 MA1619.1.18 / MA1619.1.20 MA1619.1.1 / MA1619.1.3 MA1619.1.2 / MA1619.1.4 MA1619.1.3 / MA1619.1.5 MA1619.1.4 / MA1619.1.6 MA1619.1.7 / MA1619.1.9 / MA1620.1.10 / MA1620.1.3 MA1620.1.1 MA1620.1.17 MA1620.1.18 MA1620.1.19 MA1620.1.2 MA1620.1.20 / MA1620.1.6 MA1620.1.3 MA1620.1.4 MA1620.1.5 MA1620.1.1 / MA1620.1.6 MA1619.1.19 MA1619.1.20 MA1620.1.10 MA1620.1.11 MA1620.1.12 MA1620.1.13 MA1620.1.14 MA1620.1.15 MA1620.1.16 MA1620.1.17 MA1620.1.18 MA1620.1.19 MA1620.1.20 MA1620.1.7 MA1620.1.8 MA1620.1.9 MA1619.2.1 MA1619.2.17 MA1619.2.10 / MA1619.2.14 / MA1619.2.6 MA1620.2.14 / MA1620.2.18 MA1620.2.1 / MA1620.2.17 MA1619.2.3 MA1619.2.12 / MA1619.2.16 / MA1619.2.8 MA1620.2.13 MA1620.2.19 |
| Publications: | Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE. Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility. Mol Cell Biol 33:3166-79 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.