Transcription Factor
| Accessions: | UP00621B (UniPROBE 20160601) |
| Names: | MGC10182, Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH, SLUGH1, SNAI2_D119E, WS2D, zinc finger protein SNAI2 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | zinc finger protein SNAI2: Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, |
| Length: | 155 |
| Pfam Domains: | 15-39 C2H2-type zinc finger 15-37 Zinc finger, C2H2 type 15-36 C2H2-type zinc finger 46-68 C2H2-type zinc finger 46-68 Zinc finger, C2H2 type 46-68 C2H2-type zinc finger 60-83 Zinc-finger double domain 73-94 C2H2-type zinc finger 73-94 Zinc finger, C2H2 type 74-94 C2H2-type zinc finger 87-110 Zinc-finger double domain 100-122 Zinc finger, C2H2 type 100-122 C2H2-type zinc finger 100-120 Zinc-finger of C2H2 type 100-122 C2H2-type zinc finger 114-139 Zinc-finger double domain 128-149 Zinc finger, C2H2 type 128-148 C2H2-type zinc finger 128-144 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 QSKLSEPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGA 60 61 LKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQ 120 121 THSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH |
| Interface Residues: | 4, 25, 26, 28, 29, 32, 36, 56, 57, 58, 59, 60, 62, 63, 65, 66, 69, 82, 83, 84, 85, 86, 88, 89, 90, 110, 111, 112, 113, 114, 115, 116, 117, 118, 121, 138, 139, 140, 141, 142, 144, 145 |
| 3D-footprint Homologues: | 5yel_A, 7w1m_H, 8ssq_A, 5kkq_D, 8ssu_A, 6wmi_A, 2i13_A, 8gh6_A, 1ubd_C, 7n5w_A, 6jnm_A, 1g2f_F, 6ml4_A, 4x9j_A, 6blw_A, 5ei9_F, 5kl3_A, 5und_A, 7eyi_G, 8h9h_G, 6e94_A, 7ysf_A, 6a57_A, 2gli_A, 2jpa_A, 7y3l_A, 3uk3_C, 1tf3_A, 8cuc_F, 1tf6_A, 5v3j_F, 1llm_D, 2wbs_A, 6u9q_A, 1mey_C, 7txc_E, 1f2i_J, 5k5i_A, 2kmk_A, 4m9v_C, 2lt7_A, 7y3m_I, 5k5l_F, 8gn3_A, 2drp_D, 5yj3_D |
| Binding Motifs: | UP00621B_1 wwwmrakrCACCTGyTakwhaw |
| Binding Sites: | AACACCTG AACAGGTG ACACCTGC ACACCTGT ACAGGTGC AGCAGGTG CACAGGTG CACCTGCA CACCTGCC CACCTGCG CACCTGTC CAGGTGCA CAGGTGCG CCACCTGC GCACCTGC ACAGGTGG CACCTGTA CAGGTGGA CAGGTGGC CAGGTGTA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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