DNA Binding Motif

Accessions: UP00363A_2 (UniPROBE 20160601), UP00384A_4 (UniPROBE 20160601)
Names: HLH-2_HLH-14
Organisms: Caenorhabditis elegans
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 16
Consensus: ykaaCAbCTGTCvmda
Weblogo:
PSSM: P0 A C G T
01 0.24 0.25 0.24 0.27 y
02 0.21 0.19 0.25 0.35 k
03 0.56 0.12 0.17 0.15 a
04 0.64 0.15 0.19 0.02 a
05 0.01 0.97 0.01 0.01 C
06 0.98 0.01 0.01 0.01 A
07 0 0.41 0.33 0.26 b
08 0.03 0.95 0.01 0.01 C
09 0.01 0.01 0.01 0.98 T
10 0.01 0.01 0.97 0.01 G
11 0.01 0.14 0.08 0.77 T
12 0.03 0.72 0.03 0.22 C
13 0.34 0.27 0.27 0.11 v
14 0.35 0.26 0.21 0.18 m
15 0.29 0.16 0.27 0.28 d
16 0.49 0.16 0.13 0.21 a
Type: Heterodimer
Binding TFs: UP00363A (Helix-loop-helix DNA-binding domain)
UP00384A (Helix-loop-helix DNA-binding domain)
Binding Sites: AACAGCTG
AACAGGTG
ACACCTGC
ACACCTGT
ACAGCTGC
ACAGCTGT
ACAGGTGC
ACCACCTG
AGCAGGTG
CACCTGCC
CACCTGTC
CAGCTGTC
CCACCTGC
GCAGCTGC
AACATCTG
ACATCTGC
AGCAGATG
CATCTGCC
CATCTGTC
CCATCTGC
Publications: Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed]

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