DNA Binding Site
| Accessions: | CCACCTGC (UniPROBE 20160601), MA0147.4.15 (JASPAR 2024), MA0830.3.1 (JASPAR 2024) |
| Organisms: | Mus musculus, Caenorhabditis elegans, Homo sapiens |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 8 |
| Sequence: | CCACCTGC |
| Type: | Heterodimer |
| Binding TFs: | P01106 (Helix-loop-helix DNA-binding domain, Myc amino-terminal region, Myc leucine zipper domain) P15884 (Helix-loop-helix DNA-binding domain) UP00099A (Helix-loop-helix DNA-binding domain) UP00046A (Helix-loop-helix DNA-binding domain) UP00358A (Helix-loop-helix DNA-binding domain) UP00361A (Helix-loop-helix DNA-binding domain) UP00363A (Helix-loop-helix DNA-binding domain) UP00369A (Helix-loop-helix DNA-binding domain) UP00379A (Helix-loop-helix DNA-binding domain) UP00384A (Helix-loop-helix DNA-binding domain) UP00621A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621B (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621C (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) P01106 P15884 |
| Binding Motifs: | UP00046A_1 atcmvCAGGTGcraamw UP00099A_1 ytyarCAGCTGCtvytk UP00358A_1 wAyyAwATwTrgmm UP00361A_1 agwaaaawrwhdwr UP00363A_1 cwhaaaawawwwAa UP00369A_1 mawwaawaAaadgw UP00046A_2 arrgcCAGATGkyyssg UP00099A_2 bymwcCCcryccyrty UP00358A_2 / UP00384A_3 yvsamCACCTGTTmcrg UP00361A_2 / UP00384A_5 rrmsCAsCTGbGccmt UP00363A_2 / UP00384A_4 ykaaCAbCTGTCvmda UP00369A_2 / UP00384A_8 arwwyCACCTGYthawy UP00379A_2 / UP00384A_7 mrtrmCACCTGCtaayy UP00621A_1 wmkaratrCACCTGyTakwhmk UP00621B_1 wwwmrakrCACCTGyTakwhaw UP00621C_1 tadarAwrCACCTGyTakwyad MA0147.4 CCACGTGc MA0830.3 gCACCTGc |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed] |
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