DNA Binding Motif

Accessions: UP00361A_2 (UniPROBE 20160601), UP00384A_5 (UniPROBE 20160601)
Names: HLH-2_HLH-15
Organisms: Caenorhabditis elegans
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 16
Consensus: rrmsCAsCTGbGccmt
Weblogo:
PSSM: P0 A C G T
01 0.32 0.16 0.35 0.16 r
02 0.26 0.22 0.34 0.19 r
03 0.46 0.41 0.06 0.07 m
04 0.21 0.39 0.34 0.06 s
05 0.02 0.95 0.01 0.02 C
06 0.94 0.01 0.01 0.04 A
07 0 0.38 0.55 0.07 s
08 0.06 0.79 0.14 0.01 C
09 0.01 0.01 0.01 0.96 T
10 0.01 0.01 0.95 0.02 G
11 0.06 0.26 0.42 0.25 b
12 0.09 0.03 0.72 0.16 G
13 0.14 0.41 0.24 0.21 c
14 0.17 0.55 0.13 0.15 c
15 0.30 0.50 0.13 0.07 m
16 0.07 0.12 0.20 0.61 t
Type: Heterodimer
Binding TFs: UP00361A (Helix-loop-helix DNA-binding domain)
UP00384A (Helix-loop-helix DNA-binding domain)
Binding Sites: AACACCTG
AACAGCTG
ACACCTGC
ACACCTGT
ACAGCTGC
ACAGCTGG
ACAGCTGT
ACCACCTG
ACCAGCTG
AGCAGCTG
AGCAGGTG
CACAGCTG
CACAGGTG
CACCTGCG
CAGCTGCG
CAGGTGCG
CCACCTGC
GCAGCTGC
CAGCTGGG
CCAGCTGG
Publications: Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed]

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