Transcription Factor
| Accessions: | MYC_HUMAN (HOCOMOCO 10), P01106 (JASPAR 2024) |
| Names: | bHLHe39, Class E basic helix-loop-helix protein 39, Myc proto-oncogene protein, MYC_HUMAN, Proto-oncogene c-Myc, Transcription factor p64 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 439 |
| Pfam Domains: | 1-345 Myc amino-terminal region 355-407 Helix-loop-helix DNA-binding domain 408-439 Myc leucine zipper domain |
| Sequence: (in bold interface residues) | 1 MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP 60 61 LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD 120 121 DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD 180 181 LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL 240 241 HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC 300 301 HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN 360 361 VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL 420 421 RKRREQLKHKLEQLRNSCA |
| Interface Residues: | 356, 358, 359, 360, 362, 363, 366, 367 |
| 3D-footprint Homologues: | 7z5k_B, 1an4_A, 7rcu_E, 5eyo_A, 5v0l_A, 1am9_A, 7xi3_A, 6g1l_A, 5i50_B, 7d8t_A, 4zpk_A, 5nj8_D, 5gnj_I |
| Binding Motifs: | MYC_HUMAN.H10MO.A|M01344 gasCACGTGGy MA0059.1 rAsCACGTGGt MA0147.3 ssCCACGTGcys MA0147.4 CCACGTGc |
| Binding Sites: | MA0147.4.2 MA0147.4.15 MA0147.4.11 / MA0147.4.19 MA0147.4.16 / MA0147.4.20 / MA0147.4.3 / MA0147.4.4 / MA0147.4.5 / MA0147.4.8 MA0147.4.10 / MA0147.4.17 / MA0147.4.18 / MA0147.4.9 MA0147.4.6 MA0059.1.1 MA0059.1.10 MA0059.1.11 MA0059.1.12 MA0059.1.13 MA0059.1.14 MA0059.1.15 MA0059.1.16 MA0059.1.17 MA0059.1.18 MA0059.1.19 MA0059.1.2 MA0059.1.20 MA0059.1.3 MA0059.1.4 MA0059.1.5 MA0059.1.6 MA0059.1.7 MA0059.1.8 MA0059.1.9 MA0147.3.5 MA0147.3.9 MA0147.3.10 MA0147.3.3 MA0147.3.4 MA0147.3.1 MA0147.3.11 MA0147.3.12 MA0147.3.13 MA0147.3.14 MA0147.3.15 MA0147.3.16 MA0147.3.17 MA0147.3.18 MA0147.3.19 MA0147.3.2 MA0147.3.20 MA0147.3.6 MA0147.3.7 MA0147.3.8 MA0147.4.1 MA0147.4.12 MA0147.4.13 MA0147.4.14 MA0147.4.7 |
| Publications: | Solomon D. L. C., Amati B., Land H. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 21:5372-5376 (1993). [Pubmed] Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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