Transcription Factor

Accessions: UP00099A (UniPROBE 20160601), O35885 (JASPAR 2024)
Names: 2410083I15Rik, achaete-scute complex homolog-like 2 (Drosophila), Achaete-scute homolog 2, Ascl2, Mash-2, Mash2, ASCL2_MOUSE, ASH-2
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1, JASPAR 2024 2
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Description: achaete-scute complex homolog-like 2 (Drosophila)
Length: 263
Pfam Domains: 122-171 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MEAHLDWYGVPGLQEASDACPRESCSSALPEAREGANVHFPPHPVPREHFSCAAPELVAG 60
61 AQGLNASLMDGGALPRLMPTSSGVAGACAARRRQASPELLRCSRRRRSGATEASSSSAAV 120
121 ARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETLRSAVEYIRALQRLLAEHDAV 180
181 RAALAGGLLTPATPPSDECAQPSASPASASLSCASTSPSPDRLGCSEPTSPRSAYSSEES 240
241 SCEGELSPMEQELLDFSSWLGGY
Interface Residues: 123, 124, 126, 127, 128, 130, 131
3D-footprint Homologues: 2ypa_A, 6od3_F, 2ypa_B, 2ql2_D, 5i50_B, 7z5k_B, 5gnj_I
Binding Motifs: PB0003.1 ytyarCAGCTGCtvytk
PB0107.1 bymwcCCcryccyrty
UP00099A_1 ytyarCAGCTGCtvytk
MA0816.1 arCAGCTGyy
UP00099A_2 bymwcCCcryccyrty
Binding Sites: AACAGCTG
AACAGGTG
ACACCTGC
ACAGCTGC
ACAGCTGG
ACAGCTGT
ACAGGTGC
AGCAGCTG
AGCAGGTG
CACCTGCA
CACCTGCC
CAGCTGCA
CAGCTGCC
CAGCTGCG
CAGCTGTA
CAGCTGTC
CCACCTGC
CCAGCTGC
GCACCTGC
GCAGCTGC
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.