Transcription Factor
| Accessions: | ITF2_HUMAN (HOCOMOCO 10), P15884 (JASPAR 2024) |
| Names: | bHLHb19, Class B basic helix-loop-helix protein 19, Immunoglobulin transcription factor 2, ITF-2, ITF2_HUMAN, SEF-2, SL3-3 enhancer factor 2, TCF-4, Transcription factor 4 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 667 |
| Pfam Domains: | 565-618 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWG 60 61 NGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQG 120 121 CHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGL 180 181 PSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG 240 241 MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPA 300 301 NGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA 360 361 VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHG 420 421 IIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQ 480 481 SATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKD 540 541 IKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP 600 601 QTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDA 660 661 SNHMGQM |
| Interface Residues: | 566, 569, 570, 572, 573, 574, 576, 577 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 6g1l_A, 6od3_F, 7d8t_A, 2ypa_B, 2ql2_A, 2ql2_D |
| Binding Motifs: | MA0830.1 yrCACCTGbw ITF2_HUMAN.H10MO.B|M01279 vCAGGTGyr MA0830.2 cggCACCTGccss MA0830.3 gCACCTGc |
| Binding Sites: | MA0830.3.14 / MA0830.3.16 / MA0830.3.18 MA0830.3.4 MA0830.3.5 MA0830.3.8 MA0830.3.1 MA0830.3.11 / MA0830.3.12 / MA0830.3.13 / MA0830.3.19 MA0830.2.10 / MA0830.2.5 MA0830.2.1 MA0830.2.2 MA0830.2.4 / MA0830.2.5 MA0830.2.11 / MA0830.2.6 MA0830.2.12 / MA0830.2.7 MA0830.2.13 / MA0830.2.8 MA0830.2.10 / MA0830.2.14 MA0830.2.15 MA0830.2.16 MA0830.2.17 MA0830.2.18 MA0830.2.19 MA0830.2.11 / MA0830.2.20 MA0830.2.3 MA0830.2.3 / MA0830.2.4 MA0830.2.6 MA0830.2.7 MA0830.2.8 MA0830.2.9 MA0830.2.14 MA0830.2.18 MA0830.2.12 MA0830.2.13 MA0830.2.15 MA0830.2.16 MA0830.2.17 MA0830.2.19 MA0830.2.20 MA0830.2.9 MA0830.3.6 MA0830.3.15 MA0830.3.2 MA0830.3.10 MA0830.3.17 MA0830.3.20 MA0830.3.3 MA0830.3.7 MA0830.3.9 |
| Publications: | Kophengnavong T, Michnowicz J.E, Blackwell T.K. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Molecular and cellular biology 20:261-72 (2000). [Pubmed] Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed] |
| Related annotations: | PaperBLAST |
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