Transcription Factor
| Accessions: | UP00363A (UniPROBE 20160601) |
| Names: | HLH-14 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q09961 |
| Description: | Helix Loop Helix Protein 14: hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendant |
| Length: | 147 |
| Pfam Domains: | 6-56 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 AKKNQVARNERERKRVHQVNHGFDVLRNRLQPKNHTKKWSKADTLREAVKYIQQLQVLLN 60 61 QDPQQPSVSSSTPDYTMNNSNNFNNYAVKEEFSMYLPQNYCPQNQMSVPHGDVSHNFNSP 120 121 TSSVSSSSYSPTQMCYPPVSYSNYPHH |
| Interface Residues: | 5, 9, 11, 12, 15, 16, 41 |
| 3D-footprint Homologues: | 2ypa_A, 2ql2_D, 7z5k_B, 7ssa_L |
| Binding Motifs: | UP00363A_1 cwhaaaawawwwAa UP00363A_2 ykaaCAbCTGTCvmda |
| Binding Sites: | AACAGCTG AACAGGTG ACACCTGC ACACCTGT ACAGCTGC ACAGCTGT ACAGGTGC ACCACCTG AGCAGGTG CACCTGCC CACCTGTC CAGCTGTC CCACCTGC GCAGCTGC AACATCTG ACATCTGC AGCAGATG CATCTGCC CATCTGTC CCATCTGC |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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