Transcription Factor
| Accessions: | T015198_1.02 (CISBP 1.02), UP00036A (UniPROBE 20160601), MYF6_MOUSE (HOCOMOCO 10), P15375 (JASPAR 2024) |
| Names: | Myf6, T015198_1.02;, herculin, MRF4, Myf-6, myogenic factor 6, Muscle-specific regulatory factor 4, MYF6_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, HOCOMOCO 10 3, JASPAR 2024 4 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 4 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | myogenic factor 6 |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 242 |
| Pfam Domains: | 3-93 Myogenic Basic domain 94-145 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEE 60 61 HVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRT 120 121 VANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFL 180 181 RTCSPQWPSVSDHSRGLVITAKEGGANVDASASSSLQRLSSIVDSISSEERKLPSVEEVV 240 241 EK |
| Interface Residues: | 95, 98, 99, 101, 102, 103, 105, 106 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 5i50_B, 6g1l_A, 1am9_A, 6od3_F, 7d8t_A, 2ql2_D, 2ypa_B, 2ql2_A, 5gnj_I |
| Binding Motifs: | PB0047.1 rrrgrACAGbTGtyyg PB0151.1 vsmrmCAgmCgcrcc UP00036A_1 rrrgrACAGbTGtyyg M0209_1.02 vCavcTGty UP00036A_2 vsmrmCAgmCgcrcc MYF6_MOUSE.H10MO.C|M01220 GCAGsTG |
| Binding Sites: | AACAACTG AACACCTG AACAGCTG AACAGGTG AACAGTTG ACAACTGT ACACCTGC ACACCTGT ACACGTGT ACAGCTGT ACAGGCGC ACAGGTGA ACAGTTGG CAACTGTC CACCTGAC CACCTGTC CAGCTGAC CAGCTGTC CAGGTGAC CAGTTGTC |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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