Transcription Factor
| Accessions: | UP00538A (UniPROBE 20160601) |
| Names: | AV235269, GLI-Kruppel family member GLI1, Gli1, Glioma-associated oncogene homolog, Zfp-5, Zfp5, Zinc finger protein GLI1 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | GLI-Kruppel family member GLI1: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. |
| Length: | 188 |
| Pfam Domains: | 23-41 C2H2-type zinc finger 49-76 Zinc finger, C2H2 type 69-94 Zinc-finger double domain 82-106 C2H2-type zinc finger 82-106 Zinc finger, C2H2 type 98-125 Zinc-finger double domain 112-137 Zinc finger, C2H2 type 113-137 C2H2-type zinc finger 131-155 Zinc-finger double domain 143-168 C2H2-type zinc finger 143-168 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 DLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSREL 60 61 RPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCS 120 121 KAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRG 180 181 DGPLPRAQ |
| Interface Residues: | 29, 30, 31, 32, 35, 59, 61, 62, 63, 64, 65, 66, 67, 68, 70, 71, 73, 74, 77, 94, 95, 96, 97, 98, 99, 100, 101, 102, 124, 125, 126, 127, 128, 129, 130, 131, 132, 135, 156, 157, 158, 159, 161, 162 |
| 3D-footprint Homologues: | 5v3j_F, 6wmi_A, 5ei9_F, 2i13_A, 1ubd_C, 5yel_A, 6jnm_A, 3uk3_C, 8cuc_F, 1tf3_A, 7y3l_A, 6blw_A, 6ml4_A, 2gli_A, 1tf6_A, 6a57_A, 5k5i_A, 6e94_A, 7ysf_A, 2jpa_A, 5kkq_D, 8ssq_A, 8ssu_A, 7w1m_H, 1mey_C, 5und_A, 1f2i_J, 7eyi_G, 2kmk_A, 8h9h_G, 1g2f_F, 7n5w_A, 6u9q_A, 4x9j_A, 1llm_D, 7txc_E, 5kl3_A, 5yj3_D, 4m9v_C, 2lt7_A, 7y3m_I, 2drp_D, 2wbs_A |
| Binding Motifs: | UP00538A_1 / UP00538A_2 kkgasrGGACCACCCrGrtmGm UP00538A_3 rhkvchwrCCmCCCACrctgtkk UP00538A_4 / UP00538A_5 hmsrgyrGACCACCCaGsdgGw UP00538A_6 swtmrbyaCCrCCCACattmttr |
| Binding Sites: | ACCCCCCA AGACCCCC GACCCCCC GCCACCCA GCCCACCC ACCACCCA AGACCACC AGGTGGTC CCACCCAC CCACCCAG CCCACCCA CGACCACC CGGTGGTC GACCACAC GACCACCA GACCACCC GACCTCCC GGACCACC GGCCACCC GGGCCACC |
| Publications: | Peterson KA, Nishi Y, Ma W, Vedenko A, Shokri L, Zhang X, McFarlane M, Baizabal JM, Junker JP, van Oudenaarden A, Mikkelsen T, Bernstein BE, Bailey TL, Bulyk ML, Wong WH, McMahon AP. Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev 26:2802-16 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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