Transcription Factor

Accessions: UP00370A (UniPROBE 20160601)
Names: HLH-26
Organisms: Caenorhabditis elegans
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q18053
Description: Helix Loop Helix Protein 26: hlh-26 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-26 may require UNC-37; HLH-26's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; HLH-26 is not visibly ex
Length: 209
Pfam Domains: 19-64 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 SSSPTSSSSGSPSSHGHRSETEKQRRDDTNDLLNEFKKIVQKSESEKLSKEEVLFRIVKL 60
61 LSGIQLHHESFSTSPGPIRSIKKIKSDREQVRRNKRVAAYRELRKFIALNNLSSSEEIDK 120
121 MENLKVLEIIFEVIRGKSITCTVPCLPFPILPFLPVFPVYSPLVFNSYNQFSLYPPHMPT 180
181 VQIPIVPSSSFEIDALEIEENEKDIDIVG
Interface Residues: 19, 21, 22, 25, 26
3D-footprint Homologues: 8osl_P, 4h10_A
Binding Motifs: UP00370A_1 tawgrCACGTGTchwaw
Binding Sites: AAAAAAAC
AACACGAG
AACACGCG
AACACGTG
ACACGCGT
ACACGTGC
ACACGTGT
AGCACGTG
CACGCGTG
CACGTGCA
CACGTGCC
CACGTGCG
CACGTGTA
CACGTGTC
CCACGTGC
CGCGTGTC
GCACGTGC
TAAAAAAA
TTAAAAAA
AAAAAAAA
Publications: Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed]
Related annotations: PaperBLAST

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