Transcription Factor

Accessions: T085224_1.02 (CISBP 1.02), UP00347A (UniPROBE 20160601), P42944 (JASPAR 2024)
Names: GZF3, T085224_1.02;, DEH1, J0806, NIL2, Protein GZF3, YJL110C, GZF3_YEAST
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Description: GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source;...
Notes: experiment type:PBM, family:GATA
Length: 551
Pfam Domains: 131-164 GATA zinc finger
Sequence:
(in bold interface residues)
1 MASQATTLRGYNIRKRDNVFEPKSSENLNSLNQSEEEGHIGRWPPLGYEAVSAEQKSAVQ 60
61 LRESQAGASISNNMNFKANDKSFSTSTAGRMSPDTNSLHHILPKNQVKNNGQTMDANCNN 120
121 NVSNDANVPVCKNCLTSTTPLWRRDEHGAMLCNACGLFLKLHGKPRPISLKTDVIKSRNR 180
181 KSNTNHAHNLDNFRNQTLIAELKGDCNIESSGRKANRVTSEDKKKKSSQLLMGTSSTAKI 240
241 SKKPKTESKERSDSHLSATKLEVLMSGDCSRPNLKPKLPKQDTAIYQEKLLTFPSYTDVK 300
301 EYSNSAHQSAFIKERSQFNAASFPLNASHSVTSKTGADSPQLPHLSMLLGSLSSTSISNN 360
361 GSEIVSNCNNGIASTAATLAPTSSRTTDSNPSEVPNQIRSTMSSPDIISAKRNDPAPLSF 420
421 HMASINDMLETRDRAISNVKTETTPPHFIPFLQSSKAPCISKANSQSISNSVSSSDVSGR 480
481 KFENHPAKDLGDQLSTKLHKEEEIIKLKTRINELELVTDLYRRHINELDGKCRALEERLQ 540
541 RTVKQEGNKGG
Interface Residues: 140, 141, 143, 153, 157, 158, 161, 178, 181
3D-footprint Homologues: 3dfx_B, 3vd6_C, 1gat_A, 4gat_A
Binding Motifs: UP00347A_1 twvmrrCYGATAAGrrwkwh
M0801_1.02 hGATAAGa
MA0309.1 yGATAAsr
MA0309.2 yGATAAs
Binding Sites: ACGATAAG
AGATAAGC
AGATAAGG
ATGATAAG
CCCTTATC
CCGATAAG
CCTTATCA
CCTTATCG
CGATAAGA
CGATAAGC
CTCTTATC
CTGATAAG
CTTATCAA
CTTATCGC
CTTATCTA
GATAAGCA
GATAAGGA
GATAAGGC
GCTTATCA
TCTTATCA
Publications: *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed]

Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.