Transcription Factor
| Accessions: | UP00386A (UniPROBE 20160601) |
| Names: | HLH-25 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q18054 |
| Description: | Helix Loop Helix Protein 25: hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-de |
| Length: | 267 |
| Pfam Domains: | 92-147 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 PKVIQSSMSDYRSVPYNQTPKSASERKRRNITNELINECKTIVQKSEEEHISQEVVLFRI 60 61 VKLVTGVNLESNFSSNDLSESTRRKFDTESERRKVKTEREKIRRKKQDDCYAELKFFILN 120 121 KQMGSYEQRLKLERITILEIIIDYIKHNSDLLYPETIPQILPLLAGKSTATCENKENEKP 180 181 KTRMEVKDLFPRLTFQEVQESPTSTSPLLTFPCIPMIPTTQFNVLSNYNTVPSIFSAPLR 240 241 FILPSLQILTPETSDEEENEETLDIIN |
| Interface Residues: | 93, 97, 99, 100, 103, 104 |
| 3D-footprint Homologues: | 2ypa_A |
| Binding Motifs: | UP00386A_1 rrgrCGCGTGTCCywk |
| Binding Sites: | ACACGCGC ACACGCGT ACATGCGC ACATGCGT ACCACGCG ACGCATGG ACGCGTGG CACGCATG CACGCGTA CACGCGTG CACGTGTC CATGCGTA CCACGCGC CCATGCGC CGCATGGC CGCATGTC CGCGTGGC CGCGTGTC CGTGTGTC GCGTGTCC |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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