Transcription Factor
| Accessions: | UP00591C (UniPROBE 20160601) |
| Names: | FLJ94509, GFI1_N382S, Growth factor independent protein 1, SCN2, Zinc finger protein 163, zinc finger protein Gfi-1, ZNF163 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | zinc finger protein Gfi-1: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promo |
| Length: | 193 |
| Pfam Domains: | 26-49 Zinc finger, C2H2 type 26-49 C2H2-type zinc finger 41-66 Zinc-finger double domain 55-74 Zinc-finger of C2H2 type 55-77 C2H2-type zinc finger 55-77 Zinc finger, C2H2 type 55-79 C2H2-type zinc finger 69-94 Zinc-finger double domain 83-102 Zinc-finger of C2H2 type 83-105 C2H2-type zinc finger 83-105 Zinc finger, C2H2 type 85-101 C2H2-type zinc finger 98-121 Zinc-finger double domain 111-129 C2H2-type zinc finger 111-133 Zinc finger, C2H2 type 111-120 C2H2-type zinc finger 126-149 Zinc-finger double domain 138-161 C2H2-type zinc finger 139-161 C2H2-type zinc finger 139-161 Zinc finger, C2H2 type 154-176 Zinc-finger double domain 167-190 C2H2-type zinc finger 168-190 Zinc finger, C2H2 type 169-190 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 HADKGAGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMC 60 61 GKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRF 120 121 HQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSSLITHSRKHTGFKPFGCDLCGKGFQRKV 180 181 DLRRHRETQHGLK |
| Interface Residues: | 10, 11, 12, 37, 39, 40, 43, 47, 48, 49, 52, 65, 66, 67, 68, 69, 72, 73, 83, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 106, 121, 122, 123, 124, 125, 127, 128, 131, 149, 150, 151, 152, 153, 155, 156, 177, 178, 179, 180, 181, 182, 183, 184, 188 |
| 3D-footprint Homologues: | 5v3j_F, 8ssq_A, 5kkq_D, 8ssu_A, 6wmi_A, 1tf6_A, 5und_A, 8gh6_A, 4lmg_C, 6jnm_A, 5k5i_A, 7w1m_H, 4m9v_C, 6e94_A, 7ysf_A, 2i13_A, 5yel_A, 2kmk_A, 7n5w_A, 6ml4_A, 2drp_D, 5ei9_F, 8gn3_A, 2gli_A, 8h9h_G, 7eyi_G, 2lt7_A, 2jpa_A, 1ubd_C, 3uk3_C, 1tf3_A, 2wbs_A, 4x9j_A, 1mey_C, 6blw_A, 1f2i_J, 6u9q_A, 7txc_E, 5kl3_A, 1g2f_F, 5k5l_F, 6a57_A, 7y3l_A, 8cuc_F, 1llm_D, 7y3m_I, 5yj3_D |
| Binding Motifs: | UP00591C_1 agawwaTATATCAcdGCawsyaa |
| Binding Sites: | AGATATAT AGATATCA ATATCAAA GATATATC TGATATAA GTGATATA ACTATATC ACTGATAT AGATATAG ATATATCA ATATCACG ATATCTCA ATATCTGG CACTGATA CAGATATA CAGTGATA CCGTGATA CTATATCA CTGATATA GTATATCA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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