Transcription Factor
| Accessions: | UP00594B (UniPROBE 20160601) |
| Names: | ANF, CPHD5, hAnf, HESX1_E149K, homeobox expressed in ES cells 1, Homeobox protein ANF, MGC138294, RPX |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox expressed in ES cells 1: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 ERLSLKRELSWYRGRRPRTAFTQNQIEVLENVFRVNCYPGIDIREDLAQKLNLEKDRIQI 60 61 WFQNRRAKLKRSHRESQFLMAKKNFN |
| Interface Residues: | 13, 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 71 |
| 3D-footprint Homologues: | 1mnm_C, 1le8_B, 6fqp_B, 1puf_A, 5zjt_E, 2h1k_B, 1k61_B, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1ig7_A, 5zfz_A, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 6m3d_C, 1zq3_P, 2ld5_A, 5flv_I, 7q3o_C, 4j19_B, 3a01_E, 5hod_A, 1puf_B, 1au7_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 6es3_K, 1b72_A, 4xrs_G, 2hos_A, 7psx_B, 4cyc_A, 2d5v_B, 1e3o_C, 7xrc_C, 1le8_A, 2xsd_C, 1du0_A, 3l1p_A, 6fqq_E, 4qtr_D, 8g87_X, 1o4x_A |
| Binding Motifs: | UP00594B_1 rcrwrdsCYAATTRGtkgwwsw |
| Binding Sites: | GGTAATTA ACCAATTA ACTAATTA ACTAATTG ATAATTGG ATCAATTA ATTAATTA CCAATTAA CCAATTAG CCCAATTA CCTAATTA CTAATTAA CTAATTAG CTTAATTA GATAATTA GCCAATTA GCTAATTA GTTAATTA TAATTAGA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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