DNA Binding Site
| Accessions: | en_23-1-T (DrosophilaTF 1.1), ACTAATTG (UniPROBE 20160601) |
| Organisms: | Drosophila melanogaster, Mus musculus, Homo sapiens |
| Libraries: | DrosophilaTF 1.1 1, UniPROBE 20160601 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Length: | 8 |
| Sequence: | ACTAATTG |
| Type: | Heterodimer |
| Binding TFs: | en (Homeobox domain, Engrailed homeobox C-terminal signature domain) UP00131A (Homeobox domain) UP00145A (Homeobox domain) UP00149A (Homeobox domain) UP00156A (Homeobox domain) UP00166A (Homeobox domain) UP00220A (Homeobox domain) UP00243A (Homeobox domain) UP00584A (Homeobox domain) UP00584C (Homeobox domain) UP00584F (Homeobox domain) UP00594A (Homeobox domain) UP00594B (Homeobox domain) UP00603B (Homeobox domain) UP00619C (Homeobox domain, Homeobox KN domain) |
| Binding Motifs: | UP00131A_1 dscrCTAATTAGysrkt UP00145A_1 aamAAcCAATTAAswh UP00149A_1 vrkaaTTAATTAAyrsg UP00156A_1 vmagACyAATTAgykht UP00166A_1 aamAAcCAATTArkwc UP00220A_1 wgmrcyAATTrgyGsgr UP00243A_1 hmyvCyAATTrGkbgw en TAATTa UP00584A_1 trhatvsyTAATTArktwtmtt UP00584A_2 aAgdwcgCyAATTrGckmbtgm UP00584C_2 kavwsrsCyAATTrGyysmrka UP00584F_2 mAkrdyrCyAATTrGckrwtgm UP00594A_2 ryrtkwrCyAATTrGtbgwmgw UP00594B_1 rcrwrdsCYAATTRGtkgwwsw UP00603B_2 ssgksgcAkYAATTAskmmymya UP00619C_1 AwgtwTAATyTAATTAwtwkwg |
| Publications: | Ades S.E, Sauer R.T. Differential DNA-binding specificity of the engrailed homeodomain: the role of residue 50. Biochemistry 33:9187-94 (1994). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
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