Transcription Factor
| Accessions: | UP00619C (UniPROBE 20160601) |
| Names: | homeobox protein prophet of Pit-1, Pituitary-specific homeodomain factor, PROP-1, PROP1_R99Q |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein prophet of Pit-1: This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-st |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain 38-67 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 FSPQGGQRGRPHSRRRHRTTFSPVQLEQLESAFGRNQYPDIWAQESLARDTGLSEARIQV 60 61 WFQNRRAKQRKQERSLLQPLAHLSPA |
| Interface Residues: | 14, 15, 16, 17, 18, 49, 56, 57, 59, 60, 63, 64, 67, 68, 71, 74, 75 |
| 3D-footprint Homologues: | 4j19_B, 1puf_A, 1mnm_C, 5zfz_A, 1fjl_B, 3cmy_A, 1ig7_A, 2h1k_B, 6a8r_A, 3d1n_M, 1jgg_B, 1nk2_P, 3lnq_A, 2lkx_A, 1zq3_P, 6m3d_C, 2ld5_A, 7q3o_C, 1k61_B, 6es3_K, 1le8_B, 7psx_B, 5jlw_D, 4cyc_A, 2h8r_B, 4xrs_G, 3l1p_A, 1puf_B, 1au7_A, 3a01_E, 2hdd_A, 5flv_I, 5zjt_E, 1b72_A, 2hos_A, 5hod_A, 3rkq_B, 2r5y_A, 6c1t_D, 2ky8_A, 2xsd_C, 1e3o_C, 7xrc_C, 1le8_A, 4qtr_D, 1o4x_A, 8g87_X, 1du0_A, 4xrm_B |
| Binding Motifs: | UP00619C_1 AwgtwTAATyTAATTAwtwkwg |
| Binding Sites: | AATTAATT ACCAATTA ACTAATTA ACTAATTG AGTAATTA ATAATTAA ATAATTAG ATAATTGG ATCAATTA ATTAATTA CCAATTAA CCAATTAG CTAATTAA CTAATTAG CTAATTGA GATAATTA GCTAATTA GTTAATTA TAATTAGA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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