Transcription Factor
| Accessions: | UP00220A (UniPROBE 20160601) |
| Names: | locus 1 (Drosophila), NK1 transcription factor related, Nkx-1.1, Nkx1-1, Sax2 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | O08713 |
| Description: | NK1 transcription factor related, locus 1 (Drosophila) |
| Length: | 402 |
| Pfam Domains: | 251-307 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MDGRAELPIFPRAGVPPLAASDTVPAVPEGAGAARPAAPPRPTSFSVLDILDPNKFNSRR 60 61 RRCVLLGPVVPATCAPCAPAACVAVPAASGRSPRAELERRALSAATGVAAAAGAEPTSAG 120 121 DSYRADEAEANGYSSGSGRSPTADSEDEAPEDEDEEEAPEVQDAQGTEEPRGGSGGLGAR 180 181 GSGCPGAAEVEASPVDDTAAPGPRGNSPGAPGPPATATGAGSAGSTPQGAAVTTKPKRKR 240 241 TGSDSKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQN 300 301 RRTKWKKQNPGADTSAPTGGGGGPGPGAGPGAGLPGGLSPLSPSPPMGAPLALHGPAGYP 360 361 AHSPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPAFYAPHL |
| Interface Residues: | 251, 252, 253, 254, 255, 292, 293, 295, 296, 299, 300, 303, 304, 307 |
| 3D-footprint Homologues: | 3cmy_A, 3d1n_M, 1fjl_B, 6a8r_A, 1ig7_A, 2h1k_B, 5zfz_A, 1puf_A, 1mnm_C, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 7q3o_C, 2ld5_A, 6es3_K, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 7psx_B, 1au7_A, 5hod_A, 2hos_A, 1b72_A, 5jlw_D, 4xrs_G, 3a01_E, 3rkq_B, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 8g87_X, 1k61_B, 4qtr_D, 1o4x_A, 1le8_B, 1du0_A |
| Binding Motifs: | UP00220A_1 wgmrcyAATTrgyGsgr |
| Binding Sites: | GGTAATTA AATTAGTG ACCAATTA ACTAATTA ACTAATTG AGTAATTA ATAATTAG ATTAATTA CAATTAGC CAATTAGG CCAATTAG CCTAATTA CTAATTAA CTAATTAC CTAATTGC CTTAATTA GATAATTA GCAATTAA GCTAATTA GTTAATTA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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