Transcription Factor
| Accessions: | en (DrosophilaTF 1.1), P02836 (JASPAR 2024) |
| Names: | HMEN_DROME |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P02836 |
| Length: | 552 |
| Pfam Domains: | 455-511 Homeobox domain 512-542 Engrailed homeobox C-terminal signature domain |
| Sequence: (in bold interface residues) | 1 MALEDRCSPQSAPSPITLQMQHLHHQQQQQQQQQQQMQHLHQLQQLQQLHQQQLAAGVFH 60 61 HPAMAFDAAAAAAAAAAAAAAHAHAAALQQRLSGSGSPASCSTPASSTPLTIKEEESDSV 120 121 IGDMSFHNQTHTTNEEEEAEEDDDIDVDVDDTSAGGRLPPPAHQQQSTAKPSLAFSISNI 180 181 LSDRFGDVQKPGKSMENQASIFRPFEASRSQTATPSAFTRVDLLEFSRQQQAAAAAATAA 240 241 MMLERANFLNCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLC 300 301 KAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSSAAS 360 361 SLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNE 420 421 MWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLT 480 481 ERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEE 540 541 EELEMRMNGQIP |
| Interface Residues: | 455, 456, 457, 458, 496, 497, 499, 500, 503, 504, 506, 507, 508, 511 |
| 3D-footprint Homologues: | 8ejp_B, 8pmf_A, 6m3d_C, 1zq3_P, 2lkx_A, 7q3o_C, 2ld5_A, 2hos_A, 6es3_K, 9b8u_A, 8ik5_C, 8osb_E, 7psx_B, 2hdd_A, 8eml_B, 4cyc_A, 8g87_X, 8bx1_A |
| Binding Motifs: | MA0220.1 yTAATTr en TAATTa |
| Binding Sites: | en_36-B1 / en_36-B2 en_36-T en_39-2-B en_23-1-T en_37-1-B en_20-2-B en_1-B en_1-T en_10-B en_15-B en_15-T en_16-B en_16-T en_17-B en_18-B en_18-T en_19-T en_20-1-B / en_28-3-B en_20-1-T / en_28-3-T en_20-2-T en_20-3-B en_21-B en_22-B en_22-T en_23-2-B en_23-3-B en_23-3-T en_24-B en_25-B / en_35-B en_27-7 en_27-B en_28-1-T en_29-1-T en_3-B en_30-B en_31-B en_31-T en_32-B en_33-B en_33-T en_34-B / en_8-T / en_9-T en_34-T / en_8-B / en_9-B en_37-1-T en_37-3-B en_38-1-B en_38-1-T en_38-3-B en_39-1-T en_39-14 en_39-2-T en_4-T en_40-T en_40-T1 / en_40-T2 en_41-B1 / en_41-B2 en_41-T en_42-B en_42-T en_43-3-B1 / en_43-3-B2 en_43-3-T en_45-B en_46-3-B en_46-B en_47-B en_48-1-B en_48-3-T en_48-T-2 en_49-T en_5-T en_50-T en_53-1 en_53-B en_54-B en_56-B en_57-T en_58-B en_58-T en_59-B en_59-T en_6-B en_60-B en_61-T en_62-1 en_62-B / en_72-B en_63-B en_64-B en_64-T en_65-B en_65-T en_67-T en_69-T en_7-2-B en_7-3-B en_7-3-T en_70-B en_70-T en_71-1 en_71-B en_ll-T MA0220.1.13 MA0220.1.9 MA0220.1.4 MA0220.1.8 MA0220.1.18 MA0220.1.11 MA0220.1.16 MA0220.1.1 MA0220.1.10 MA0220.1.12 / MA0220.1.17 MA0220.1.14 MA0220.1.15 MA0220.1.19 MA0220.1.2 MA0220.1.20 MA0220.1.3 MA0220.1.5 MA0220.1.6 MA0220.1.7 |
| Publications: | Ades S.E, Sauer R.T. Differential DNA-binding specificity of the engrailed homeodomain: the role of residue 50. Biochemistry 33:9187-94 (1994). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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